贵州医科大学学报

2016, v.41;No.184(01) 5-7

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贵州省汉族原发性高血压CYP17A1基因的多态性
Interrelation between CYP17A1 Gene Polymorphisms and Essential Hypertension in Han Nationality of Guizhou Province

周启保;刁晓艳;张颖;张旺德;赵孝梅;官志忠;
ZHOU Qibao;DIAO Xiaoyan;ZHANG Ying;ZHANG Wangde;ZHAO Xiaomei;GUAN Zhizhong;Department of Internal Medicine-Cardiovascular,Affiliated Hospital of Guizhou Medical University;The Key Laboratory of Molecular Biology,Guizhou Medical University;

摘要(Abstract):

目的:探讨贵州省汉族原发性高血压(EH)人群CYP17A1基因rs11191548位点多态性。方法:选取贵州汉族人群的EH患者198例(EH组)和健康体检者199例(对照组),应用Taq Man探针方法观察两组被检者CYP17A1基因rs11191548位点的基因型及等位基因频率分布。结果:在EH组和对照组均检测出CYP17A1基因rs11191548位点3种基因型,两组间基因型分布及等位基因频率差异有统计学意义(P<0.05)。结论:CYP17A1基因rs11191548多态性与贵州省汉族人群EH可能相关。
Objective: To investigate the relationship between rs11191548 loci polymorphisms in CYP17A1 gene with essential hypertension in Han inhabitants of Guizhou province. Methods: Taq Man probe method was utilized to analyze the genotype of rs11191548 polymorphism in CYP17A1 gene,which was performed on 198 selected EH inhabitants as EH group and 199 normal inhabitants as control group. Results: Three genotypes of rs11191548 loci in CYP17A1 gene was detected in both groups. The genotype distribution and allele frequency distribution in two group has statistical difference( P < 0. 05). Conclusions: The rs11191548 loci gene polymorphism of CYP17A1 may be associated with EH in Han inhabitants of Guizhou province.

关键词(KeyWords): 高血压;CYP17A1;基因多态性;等位基因;基因型;汉族;贵州
hypertension;CYP17A1;gene polymorphism;alleles;genotype;Han nationality;Guizhou

Abstract:

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基金项目(Foundation): 国家科技支撑计划项目(2013BAI05B03);; 贵州省“2011协同创新中心”[黔教合协同创新中心(2014)06号]

作者(Author): 周启保;刁晓艳;张颖;张旺德;赵孝梅;官志忠;
ZHOU Qibao;DIAO Xiaoyan;ZHANG Ying;ZHANG Wangde;ZHAO Xiaomei;GUAN Zhizhong;Department of Internal Medicine-Cardiovascular,Affiliated Hospital of Guizhou Medical University;The Key Laboratory of Molecular Biology,Guizhou Medical University;

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DOI: 10.19367/j.cnki.1000-2707.2016.01.003

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