张蓓,秦际德,何艳,沈正,刘兴德
ZHANG Bei,QIN Jide,HE Yan,SHEN Zheng,LIU Xingde(Department of Cardiovascular Medicime the Affiliated Hospital of Guiyang Medical College

• 1:贵阳医学院附院超声中心
• 2:贵阳医学院附院心血管科
• 3:贵阳医学院

摘要(Abstract)：

目的:探讨Tei指数评价心肌缺血-再灌注家兔左心功能的价值。方法:16只家兔随机分为2组,假手术组和缺血再灌注组;180min后对2组家兔行心脏超声检查,测量家兔左心室Tei指数、射血分数(EF)及左室短轴缩短率(FS)等指标;取各组家兔血清测超氧化物歧化酶(SOD)和丙二醛(MDA)。结果:2组Tei指数、EF及FS比较均有显著性差异(P<0.05),血清SOD及MDA测定结果差异亦有统计学意义(P<0.05)。结论:应用Tei指数可较好地评价心肌缺血-再灌注家兔左心功能的改变。
Objective:To explore the value of Tei index in evaluation of left ventricular function of rabbits after ischemic reperfusion. Methods:Sixteen rabbits were divided into 2 groups randomly (8 in each):sham operation group (group S) and ischemia reperfusion (R/I) group (group R). Rabbits' hearts were checked by ultrasonography and heart function was detected by monitoring of Tei,ejection fractino (EF),and fractional shortening (FS) of left ventricular in 180min after reperfusion. Enzymatic dynamics of myocardimn SOD and MDA in serum of these rabbits were detected. Results:There were significant differences of Tei,EF,and FS between the two groups (P<0.05). The serum SOD level of group S was lower than that of group R,and the serum MDA level of group S was higher than that of group R. The differences were significant. Conclusion:Tei index is helpful in evaluation of rabbit cardiac function after ischemical reperfusion.

关键词(KeyWords)： Tei指数;心肌再灌注损伤;超氧化物歧化酶;丙二醛;兔
Tei index; myocardial reperfusion injury; superoxide dismutase malondialdehyde; rabbits

Abstract:

Keywords:

基金项目(Foundation): 贵州省高层次人才科研条件特助经费项目TZJF(2006)12号

作者(Author): 张蓓,秦际德,何艳,沈正,刘兴德
ZHANG Bei,QIN Jide,HE Yan,SHEN Zheng,LIU Xingde(Department of Cardiovascular Medicime the Affiliated Hospital of Guiyang Medical College

DOI: 10.19367/j.cnki.1000-2707.2010.03.005

参考文献(References)：

• [1]Lopes LR,Joao I,Vinhas H,et al.Evaluation of systolic and systo-diastolid:the Tei index in acute myocardial infarction treated with acute reperfusion therapy-early and late evalu-ation[J].Rev Port Cardiol,2007(6):649-656.
• [2]刘宏伟,盖鲁粤,智光.Tei指数与有创性心功能参数的相关性研究[J].中国超声医学杂志,2007(11):801-803.
• [3]Uzunhasan I,Bader K,Okcun B,et al.Correlation of the Tei index with left ventricular dilatation and mortality in patients with acute myocardial infarction[J].Int Heart J,2006(3):331-342.
• [4]史卫国,牟晓雯,孙学玉,等.急性心肌梗死患者Tei指数与左心室充盈模式及预后的关系[J],中国临床医学影像杂志,2009(6):408-411.
• [5]余红萍,陈剑,张赵盾,等.早期高血压患者左室Tei指数测定[J].心脑血管病防治,2005(3):132-133.
• [6]Ren JH,Chen YP.Effects of ischemic postconditioning on myocardial ischemia-reperfusion injury to isolated rat heart[J].Chin J Anesthesiol,2007(1):84-87.

文章评论(Comment)：