贵州医科大学学报

1996, (01) 14-16

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古尼拟青霉抗癌作用的实验研究
Experimental Study on Anti-cancer Effect of Paecilomyces Gunnii

李淑芳;鲍淑娟;林文琴;
Li Shufang Department of Pharmacology,Guiyang Medical College

摘要(Abstract):

报道古尼拟青霉的体内、体外抗癌作用。实验结果表明:给小鼠按体重每天灌服5或10g/kg的古尼拟青霉,连续用药7d 后,对淋巴肉瘤180(S_(180))、子宫颈癌_(14)(U_(14))及肝癌实体型均有明显抑制作用,肿瘤抑制率均大于30%;体外抗癌实验结果亦表明,本品能显著降低肿瘤活细胞率。
This paper reports the results of experimental study in vivo anti-cancer effect of Paecilomyces gunnii in mice.Crude water extract of Paecilomyces gunnii was orally given to mice at doses of 5g/(kg ·d)and 10g/(kg·d)for seven consecutive days.The inhibition rates of iymphosarcoma 180 (S_(180)),carcinoma of uterine cervix 14(U_(14)),and hepatoceller carcinoma in mice were obviously higher(exceeded 30%)than that of control,and there were statistically significant differences be- tween the inhibition rates of treated groups and that of control group.The in vitro experimental results also indicates that Paecilomyces gunnii could significantly reduce living rate of cancer cells.

关键词(KeyWords): 古尼拟青霉;抗癌作用;抑制率;活细胞率
Paecilomyces gunnii;anti-cancer effect;inhibition rate;living cell rate

Abstract:

Keywords:

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作者(Author): 李淑芳;鲍淑娟;林文琴;
Li Shufang Department of Pharmacology,Guiyang Medical College

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DOI: 10.19367/j.cnki.1000-2707.1996.01.007

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