贵州医科大学学报

1990, (03) 204-206

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用ABC方法检测肺癌病人外周血T细胞亚群
Identification of the T-Sabset in Peripheral Blood Tymphocytes in Patients with Lung Cancer Using ABC Method

弋琼;冯家兴;
Yi Qiong Guizhou Cancer lnstitute

摘要(Abstract):

用OKT单克隆抗体和ABC系统检测了正常人,非肿瘤肺疾患病人及肺癌病人三组人群外周血T淋巴细胞亚群。结果表明用该法测得的正常人组OKT_4~+细胞,OKT_8~+细胞均值同其它方法所得结果相近;非肿瘤病人OKT_8~+细胞增多,致使OKT_4~+/OKT_8~+细胞比值明显低于正常人。肺癌病人OKT_4~+,OK_8~+细胞均有显著变化。提示肿瘤病人体内免疾调节明显紊乱。
The T-subset in peripheral blood lymphocytes has been determied by OKT monoclonal antibody and ABC system in normal controls, patinents with non malignant pulmonary diseases and lung carcinoma. The results showed that the mean value of OKT_4~+cells amd OKT_8~+cells were similar to that of other assays. In case of patients with non malignant diseases, the OKT_4~+/OKT_8~+ratio was significantly decreased because of the increase of percntage of OKT_8~+cells. Both the OKT_4~+and OKT_8~+ Cells changed remarkably, it indicated the immune regulation function has been greatly disturbed.

关键词(KeyWords): 单克隆抗体;免疫酶技术;肺癌;T—淋巴细胞
momoclonal antibody;immunoenzyme technics;lung cancer;T lymphocytes

Abstract:

Keywords:

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作者(Author): 弋琼;冯家兴;
Yi Qiong Guizhou Cancer lnstitute

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DOI: 10.19367/j.cnki.1000-2707.1990.03.010

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