王鹏娇,张敏,孔祥林,高秀丽
WANG Pengjiao,ZHANG Min,KONG Xianglin,GAO Xiuli(School of Pharmacology

• 1:贵阳医学院药学院

摘要(Abstract)：

目的:优选大红袍妇炎宁胶囊的最佳水提工艺。方法:应用L9(34)正交实验,以丹酚酸B和芍药苷提取量为考察指标,以加水量、提取时间和提取次数为考察因素,每个因素取3个水平进行正交实验。结果:大红袍妇炎宁胶囊的最佳水提工艺条件为A2B1C2,即提取2次,第1次加9倍量水,第2次加8倍量水,每次提取1 h。结论:优选的水提工艺稳定可行。
Objective:To optimize water extracting technology of Dahongpaofuyanning capsule(DFC)with orthogonal test.Methods: L9(34) orthogonal experiment was carried out with extraction quantity of salvianolic acid B and paeoniflorin as evaluation indexes,and water amount,extraction duration and extraction frequency as testing factors.Three levels of each factor were designed for the orthogonal experiment.Results: The optimal water extracting technology of DFC was A2B1C2 which meant extracting twice,adding ninefold water at the first time and adding eightfold water at the second time.extracting for 1 hour each time.Conclusions: This optimized water extracting technology of DFC is stable and feasible.

关键词(KeyWords)： 芍药苷;大红袍妇炎宁胶囊;水提工艺;正交实验;丹酚酸B
paeoniflorin;Dahongpaofuyanning capsules;water extracting technology;orthogonal experiment;lithospermate B

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技厅项目(合同号:黔科合中药专字[2007]5015号);; 贵阳市科技局项目(合同号:[2007]筑科农合同字第121号)

作者(Author): 王鹏娇,张敏,孔祥林,高秀丽
WANG Pengjiao,ZHANG Min,KONG Xianglin,GAO Xiuli(School of Pharmacology

DOI: 10.19367/j.cnki.1000-2707.2011.01.008

参考文献(References)：

• [1]李奉勤,史冬霞.正交设计在中药制粒工艺研究中的应用概况[J].中国药业,20065(13):67-686.
• [2]陈象青,刘圣,方炎,等.多指标正交试验优选当归提取工艺[J].中国实验方剂学杂志,2010(8):25-28.
• [3]高秀丽,蒋蒨,王鹏娇,等.HPLC测定大红袍妇炎宁胶囊中的丹参酮IIA和丹酚酸B[J].华西药学杂志,2008(4):478-480.
• [4]何讯,李勇军,王爱民,等.反相高效液相色谱法测定妇科调经胶囊中芍药苷的含量[J].贵阳医学院学报,2006(2):118-123.
• [5]国家药典委员会.中华人民共和国药典(一部)[S].北京:化学工业出版社,2005:109.
• [6]梅全喜,曾聪彦,周小军.正交法优选鼻咽解毒颗粒的水提工艺[J].中华中医药学刊,2010(7):1483-1484.

文章评论(Comment)：