李新华,张惠琴
LI Xinghua1,ZHANG Huiqin2(1.Department of Health Statistics

• 1:贵阳医学院卫生统计学教研室
• 2:贵阳医学院附院耳鼻咽喉科 贵州贵阳550004
• 3:贵州贵阳550004

摘要(Abstract)：

目的:探讨不同算法的区间删失Cox模型在临床随访研究中的应用。方法:用三种不同算法的区间删失Cox模型对鼻咽癌患者随访研究资料进行了分析。结果:三种不同算法的区间删失Cox模型分析的结果相当接近。结论:区间删失Cox模型可作为临床随访研究的有效工具,三种软件中,stpm程序使用较为方便,且用途较为广泛。
Objective: To explore the application of interval censored Cox model with different algorithm in clinical follow-up study.Methods: The data of follow-up study for nasopharyngeal carcinoma patients were analyzed by interval censored Cox model with three algorithm.Results: The results analyzed by interval censored Cox model with different algorithm were very identical.Conclusion: The interval censored Cox model is an available tool for the clinical follow-up study.Among the three kinds of software,the Stpm program is easier for use and has relatively extensive applying scope.

关键词(KeyWords)： 区间删失Cox模型;随访研究;癌;鼻咽肿瘤
interval censored Cox model;follow-up studies;carcinoma;nasopharyngeal neoplasms

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 李新华,张惠琴
LI Xinghua1,ZHANG Huiqin2(1.Department of Health Statistics

DOI: 10.19367/j.cnki.1000-2707.2007.02.012

参考文献(References)：

• [1]丁元林,等.慢性流行病学研究中Cox回归模型及其进展[J].广西医学,2003(12):2446-2449.
• [2]张菊英,韦健,丁元林.区间截尾Cox比例风险模型及其应用[J].中国卫生统计,2002(5):291-292.
• [3]胡雨田.咽科学[M].第2版.上海:科学技术出版社,2000:406.
• [4]Joly P,Letnneur L,Ahmadou Alioum A,et al.PHMPL:acomputer program for hazard estimation using a penalizedlikelihood method with interval-censored and left-trun-cated data[J].Computer Method And Programs in Bio-medicine,1999(60):225-231.
• [5]Royston P.Flexible parametric alternatives to the Coxmodel,and more[J].Stata Journal,2001(1):1-28.
• [6]Royston P.MK B Parmar.Flexible proportional-hazardsand proportional-odds models for censored survival data,with application to prognostic modelling and estimation oftreatment effects[J].Statistics in Medicine 2002(21):2175-2197.
• [7]Wei Pan.Extending the iterative convex minorant algo-rithm to the Cox model for interval-censored data[J].Journal of Computational and Graphical Statistics,1999(78):109-120.
• [8]Henschel V,Hei C,Mansmann U.Intcox:Compendiumto apply the iterative convex minorant algorithm to intervalcensored event data[M].University of Heidelberg,2004:1-12.
• [9]Rosoner B.Fundamentals of Biostatistics[M].5th edi-tion.C.USA:Duxbury Press,2000:733-736.

文章评论(Comment)：