贵州医科大学学报

2007, No.125(02) 131-134

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海洛因依赖期间大鼠胃窦5-羟色胺免疫反应细胞形态和功能变化
Studies on Morphological and Functional Changes of Hydroxytryptamine Immunoreactive Cells in Gastric Antrum in Heroin Dependent Rats

夏白娟;梁文妹;
XIA Baijuan,LIANG Wenmei(Department of Histo-Embryology,Guiyang Medical college,Guiyang 550004,China)

摘要(Abstract):

目的:探讨胃窦5-羟色胺(5-HT)免疫反应细胞在海洛因依赖期间的作用。方法:应用免疫组织化学SABC法及图像分析方法研究海洛因依赖期间大鼠胃窦5-HT-IR细胞平均灰度值和细胞计数的变化。结果:与正常组及盐水组比较,海洛因依赖组大鼠胃窦5-HT-IR细胞数量显著增加(P<0.01),细胞的平均灰度值较正常和盐水对照组显著降低,在第24天时变化最为明显(P<0.01)。结论:大鼠胃窦5-HT-IR细胞通过增加细胞数和增强5-HT的分泌,参与了机体在海洛因依赖期的调节过程。
Objective: To explore the possible function of hydroxytryptamine immunoreactive(5-HT-IR) cells in gastric antrum of rats during heroin dependence.Methods: Immunohistochemical SABC method and imagine analysis were used to observe the changes of the mean gray degree and number of 5-HT IR cells in gastric antrum of rats during heroin dependence.Results: As compared with rats in normal control group and saline control group,the number of 5-HT-IR cells increased(P<0.01),and the mean gray degree of 5-HT-IR cells decreased in rats of heroin dependent group.The peak of these changes occurred on the 24th day.Conclusions: 5-HT-IR cells might involve in the body physiological regulation during heroin dependence by increasing the cell numbers and enhancing the synthesis of hydroxytryptamine.

关键词(KeyWords): 海洛因依赖;胃窦;5-羟色胺;免疫组织化学;大鼠
heroin dependence;gastric antrum;5-tryptamine;immunohistochemistry;rats

Abstract:

Keywords:

基金项目(Foundation): 贵州省优秀科技教育人才省长专项资助项目[黔科教办(2001-3)];; 贵州省教育厅科研基金资助项目[黔教科(1999)]

作者(Author): 夏白娟;梁文妹;
XIA Baijuan,LIANG Wenmei(Department of Histo-Embryology,Guiyang Medical college,Guiyang 550004,China)

Email:

DOI: 10.19367/j.cnki.1000-2707.2007.02.007

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