血Ca~(2+)、CRP、纤维蛋白原和淀粉酶联合检测用于急性胰腺炎的评价The Value of Combined Detection of Blood Calcium,CRP,Fibrinogen and Amylase in Evaluation of Acute Pancreatitis Severity
苏艳丽,吴昌学,张帅民
SU Yanli,WU Changxue,ZHANG Shuaimin
摘要(Abstract)：
目的:观察急性胰腺炎(AP)患者血Ca2+、C-反应蛋白(CRP)、纤维蛋白原、淀粉酶含量与AP严重程度的关系。方法:107例AP患者,按病情严重程度分为轻度AP(MAP)组59例,中度AP(MSAP)组23例及重度AP(SAP)组25例,测定3组患者入院时血Ca2+、CRP、纤维蛋白原、淀粉酶含量,分析其变化及与APACHE II评分的相关性。结果:与MAP组比较,MSAP组及SAP组患者血Ca2+降低,差异有统计学意义(P<0.05);SAP组CRP升高,差异有统计学意义(P<0.01);3组血淀粉酶和纤维蛋白原差异无统计学意义(P>0.05);APACHEⅡ评分与CRP、纤维蛋白原呈正相关(r=0.432,P<0.01;r=0.223,P<0.05),与血Ca2+呈负相关(r=-0.312,P<0.01)。结论:监测AP患者血Ca2+、CRP及纤维蛋白原水平及变化可评估AP患者的病情。
Objective: To investigate the relationship of calcium,C-reactive protein( CRP),fibrinogen,amylase levels in serum with the severity of acute pancreatitis( AP). Methods: A total of 107 AP patients were divided into mild AP group( MAP group) with 59 cases,moderate AP group( MSAP group) with 23 cases and severe AP group( SAP group) with 25 cases. Levels of calcium,CRP,fibrinogen,amylase in serum of these patients were detected on admission to analyze the correlation with APACHE II score. Results: Compared with MAP group,the serum content of calcium was significantly decreased in MSAP and SAP groups( P < 0. 05); the serum content of CRP was significantly increased in SAP( P < 0. 01); the serum contents of amylase and fibrinogen of the 3 groups had no significant difference( P > 0. 05); APACHE Ⅱ score were positively correlated with CRP,fibrinogen( r= 0. 432,P < 0. 01; r = 0. 223,P < 0. 05),and negatively correlated with calcium( r =- 0. 312,P <0. 01). Conclusion: Monitoring the serum contents of calcium,CRP,fibrinogen is helpful to evaluate the severity of AP patients.
关键词(KeyWords)：
胰腺炎;血钙;C-反应蛋白;纤维蛋白原;淀粉酶
pancreatitis;serum calcium;C-reactive protein;fibrinogen;amylase
基金项目(Foundation): 贵州省科技厅基金[黔科合LG字(2012)009号]
作者(Author):
苏艳丽,吴昌学,张帅民
SU Yanli,WU Changxue,ZHANG Shuaimin
DOI: 10.19367/j.cnki.1000-2707.2015.02.018
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