耿红霞
GENG Hongxia

• 1:青海省人民医院急诊内科

摘要(Abstract)：

目的:探讨急性肺栓塞(APE)患者血浆脑钠肽(BNP)、肌钙蛋白Ⅰ(c TnⅠ)与D-二聚体(D-dimer)水平的临床意义。方法:选取52例APE患者,根据栓塞面积分为大面积APE组与非大面积APE组,测定两组患者的BNP、c TnⅠ、D-二聚体水平、右心功能不全发生率及病死率。结果:大面积APE组BNP、c TnⅠ值显著高于对非大面积APE组,差异有统计学意义(P<0.05),两组D-dimer比较差异无统计学意义(P>0.05);大面积APE患者右心功能不全发生率及病死率(73.1%、26.9%)均显著高于非大面积APE组(15.4%、3.8%),差异有统计学意义(P<0.05)。结论:血浆BNP、c TnⅠ水平检测可用于APE患者危险分层及预后评估,D-dimer水平检测可作为诊断APE的排除指标。
Objective: To discuss the clinical significance of brain natriuretic peptide( BNP),cadiac troponin Ⅰ( c TnⅠ) and D-dimer detection in patients with acute pulmonary embolism( APE).Methods: Fifty-eight patients with APE were divided into the Massive PE group( n = 26) and the NonMassive PE group( n = 26) according to the embolization area. Then the level of BNP,c TnⅠand D-dimer,right heart function failure rate and mortality were compared between the two groups. Results:BNP,c TnⅠ in the Massive PE group were significantly higher than those of Non Massive PE group( P < 0. 05),but there was no statistical difference in D-dimer between two groups( P > 0. 05). The incidence of right heart function failure and the fatality rate in the Massive PE group was 73. 1% and26. 9%,significantly higher than 15. 4% and 3. 8% in the Non Massive PE group( P < 0. 05 or P <0. 01). Conclusion: Detection of plasma BNP,c Tn I levels can estimate the risk stratification and prognosis in patients with APE,the detection of D-dimer level can be used as an exclusion marker for diagnosis of APE.

关键词(KeyWords)： 血浆;脑钠肽;肌钙蛋白Ⅰ;D-二聚体;急性肺栓塞;病死率
plasma;brain natriuretic peptide;cadiac troponin Ⅰ;D-dimer;acute pulmonary embolism;case fatality rate

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 耿红霞
GENG Hongxia

DOI: 10.19367/j.cnki.1000-2707.2015.10.017

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