吴昌学,苏艳丽,李毅,齐晓岚,肖雁,邓婕,张婷,何燕,单可人,谢渊,禹文峰,官志忠
WU Changxue,SU Yanli,LI Yi,QI Xiaolan,XIAO Yan,DENG Jie,ZHANG Ting,HE Yan,SHAN Keren,XIE Yuan,YU Wenfeng,GUAN Zhizhong

• 1:贵州医科大学分子生物学重点实验室
• 2:贵州医科大学学报编辑部
• 3:贵阳护理职业学院检验系

摘要(Abstract)：

目的:了解贵州省毕节燃煤污染型地方性氟中毒病(地氟病)病区人群经综合治理后的血常规指标状况。方法:分别选取毕节地氟病区未综合治理村和经综合治理乡镇各100人作为未综合治理组和综合治理组,长顺县100人作为对照1组;另分别选取毕节地氟病重病区综合治理时间<1年和综合治理时间>3年乡镇各100人作为治理时间长组和治理时间短组,贵阳白云区100人为对照2组;采集所有受检者空腹静脉血2 m L检测白细胞(WBC)、红细胞(RBC)、血红蛋白(Hb)、红细胞压积(HCT)及血小板计数(PLT),分别观察5项血液学指标的变化。结果:RBC、Hb异常率未综合治理组>经综合治理组>对照1组、治理时间短组>治理时间长组>对照2组,差异有统计学意义(P<0.05);WBC在相应组间比较,差异无统计学意义(P>0.05);RBC、HCT及PLT在未综合治理组、经综合治理组和对照1组间同性别比较,差异有统计学意义(P<0.05),而Hb仅男性间比较,差异有统计学意义(P<0.05),未综合治理组<经综合治理组<对照1组;RBC、Hb、HCT在治理时间短组、治理时间长组和对照2组间按性别比较,差异有统计学意义(P<0.05);治理时间长组与对照2组女性PLT、治理时间长组与治理时间短组男性PLT比较,差异有统计学意义(P<0.05),均表现为治理时间短组<治理时间长组<对照2组。结论:贵州省毕节地氟病区人群血常规指标随综合治理及治理时间的增加有所改善。
Objective: To investigate the blood routine index of people in the Bijie coal burning pollution endemic fluorosis disease( fluorosis) district after comprehensive care management. Method:Totally 200 people lives in a non-endemic fluorosis comprehensive management area and management area in Bijie were selected as non-management group and management group,another 100 people from the village of comprehensive management as control group. 200 people in the endemic fluorosis area in Bijie as long time management group and short time management group( less than one year and more than three years). 100 healthy people from Baiyun district of Guiyang as control group. All subjects were collected 2 m L fasting Venous blood respectively to detecting blood indicators such as indicators of leukocytes( WBC),red blood cell( RBC),hemoglobin( Hb),hematocrit( HCT),platelet count( PLT) and so on. Then compare the abnormal rate of RBC and Hb and the others indicators changes respectively. Results: Comparing the abnormality rate of RBC,Hb,the data showed the trend of abnormality rate: non-management group > management group > control group,the treatment of short group > governance length group > control group,and the differences were statistically significant( P < 0. 05). The change of WBC was not statistically significant among the groups( P > 0. 05). Comparing RBC,HCT,PLT,Hb in the non-treatment group,treatment group and control group by gender,both were statistically significant( P < 0. 05). Hb only showed statistically significant in male difference( P < 0. 05). Non-management group < management group < control group; RBC,HCT,PLT compared in gender in long time management and short time management and control group,group and control group by gender,differences were statistically significant( P < 0. 05). Comparing female PLT of long time group and control group,male PLT of long time group and control group,differences were all statistically significant( P < 0. 05). Results all showed that short-group < governance long time group < control group. Conclusion: The blood routine index of fluorosis population has improved after a comprehensive care management.

关键词(KeyWords)： 氟化物中毒;血细胞;白细胞;血小板;血红蛋白;贵州;毕节
fluoride poisoning;blood cells;white blood cells;platelets;hemoglobin;Guizhou;Bijie

Abstract:

Keywords:

基金项目(Foundation): 国家科技支撑计划项目(2013BAI05B03);; 国家自然科学基金资助项目(81160335);; 贵州省科技厅重点项目[黔科合计Z字(2012)4010];; 贵州省科技计划课题(国际合作项目)[黔科合外G字(2011)7014号];; 贵州2011协同创新中心建设项目[黔教合协同创新中心(2014)06];; 贵州省科技厅科技计划课题资助[黔科合LG字(2012)009号]

作者(Author): 吴昌学,苏艳丽,李毅,齐晓岚,肖雁,邓婕,张婷,何燕,单可人,谢渊,禹文峰,官志忠
WU Changxue,SU Yanli,LI Yi,QI Xiaolan,XIAO Yan,DENG Jie,ZHANG Ting,HE Yan,SHAN Keren,XIE Yuan,YU Wenfeng,GUAN Zhizhong

DOI: 10.19367/j.cnki.1000-2707.2015.10.003

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