猫SI、SII对尾核痛相关单位的下行调制作用初探A Preliminary Study of the Descending Modulating from Somatosensory Areas Ⅰ and Ⅱ on Pain Relating Units of Caudate Nucleus in Cat
杨国仁,殷松生
Yang Guoren, Yin Songsheng Department of Physiology
摘要(Abstract):
实验用清醒麻痹猫进行观察。结果表明,刺激SⅠ区,尾核头部痛相关单位多数受到抑制。36.36%的单位在刺激SⅠ区后表现先抑制后兴奋的现象。64.29%的单位在刺激SI区后出现抑制效应时,单位放电即刻停止一定时间。刺激SⅡ区的效应与刺激SⅠ区类同。用GABA改变SⅡ区的正常机能状态,刺激SⅠ区的效应,在26个痛相关单位中有13个单位显示激活或相反,而对照组没有改变。提示SⅠ区对痛相关单位有单独的抑制效应。而在SⅠ区对尾核头部痛相关单位的下行调制中SⅡ区起一定的协同作用。
Experiments were performed on 41 conscious paralyzed cats. Results srowed that when the somatosensory area Ⅰ(SⅠ)was stimulated most pain relating units inhibited. About 36.36% of the units(8/22) showing excitatory effects after stimulating SI had a phenomenon of being inhibited initially and excited subsequently(inhibiting time 4.21±0.75sec). About 64.29% of the units(36/56) showing inhibitory effects after stimulating SⅠ had a phenomenon of that the discharges of the units stopped immedtely for a period of time(6.75±1.62sec). The effects of stimulating SⅡ were similar to that of SⅠ when the state of normal function of SⅡ had been changed by applying GABA on it, effects of stimulating SⅠ were as follow: of 26 pain units, 13 units showed activation or catrary; while the effects of control group remained uncharged. These results indicate that SⅠ has an inhibitory effects solely on pain relating units and SⅡ plays a certain role in presence of the descending modulation from SⅠ on pain relating units in the head of caudate nucleus of the cat.
关键词(KeyWords):
躯体感觉皮质;尾状核;疼痛;电刺激;猫
somatosensory cortex;caudate nucleus;pain;electric stimulation;cats
基金项目(Foundation):
作者(Author):
杨国仁,殷松生
Yang Guoren, Yin Songsheng Department of Physiology
DOI: 10.19367/j.cnki.1000-2707.1992.04.007
参考文献(References):
- 1 徐维,等.大脑皮层与针刺镇痛关系.中华神经科杂志,1979,12:68~72
- 2 上海第一医学院基础医学部针麻研究组.纳洛酮对针刺抑制家兔大脑皮层牙髓诱发电位的影响.针刺麻醉,1979(1) :46~50
- 3 韩湘文,等.皮层内刺激或冷冻阻滞SⅠ区对猴操作式条件反射和针刺镇痛作用的影响.生理学报,1982,34(2) :165~172
- 4 黄忠致,等.躯体感觉Ⅱ区皮层内微刺激对猕猴回避性操作式条件反射和针刺镇痛的影响.生理学报,1983,35(3) :286~294
- 5 潘贵书,等.皮层第二体感区下行活动对尾核神经元伤害性反应的影响. 应用生理学杂志,1990,6(4) :324~328
- 6 Snider R S, et al. A stereotaxic atlas of the cat brain. Chicago: University of Chicago press, 1961
- 7 Reiffel J A. Electrophysiologic testing for recurrent syncope. Arrhythmias an dconduction disturbances, 1986, 7:65
- 8 Lamour Y, et al. Normal response to noxious stimulation in rat somotosensory coraex. Neurosci Lett, 1982, 29: 35-40
- 9 洪炎国,等.电刺激家兔大脑皮层体感区对丘脑束旁核痛敏单位电活动的影响.生理学报,1983,35(2) :156~162
- 10 Jones E G, et al. Connexions of the somatic sensory cortex of the Rhusus monkey. I,Ipsilateral cortical connexions. Brain, 1969, 92: 477-502
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