贵州医科大学学报

1998, (03) 3-5

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血清神经元特异性烯醇酶和胃泌素用于肺癌的临床价值
Clinical Value of Measurement of Serum Neuron Specific Enolase and Gastrin for Lung Cancer

周建奖,王仁敏,润丹
Zhou Jianjiang, et al Guizhou Institute of Tumour Prevention and Cure

摘要(Abstract):

检测30例正常对照、25例良性肺疾病、55例非小细胞肺癌(NSCLC)和15例小细胞肺癌(SCLC)患者血清神经元特异性烯醇酶(NSE)和胃泌素及其在治疗前后的动态变化,结果显示,血清NSE和胃泌素在4组间差异有极显著性(P<0001),NSE均值分别为822、1084、1464和3200μg/L,胃泌素均值分别为5947、8200、22153和35686ng/L。以203μg/L(NSE)和814ng/L(胃泌素)为正常参考值上限,NSE阳性率分别是80%(SCLC)和1454%(NSCLC),胃泌素分别是80%(SCLC)和6363%(NSCLC)。肺癌治疗后血清NSE和胃泌素在SCLC组均显著下降(P<0001),而NSCLC组仅有胃泌素降低(P<0001)。因此,NSE主要用于SCLC的诊断、组织学分型及疗效监测,而胃泌素可以用于各型肺癌,两者联合可以提高临床应用价值。
To study the clinical value of measurement of serum neuron specific enolase (NSE) and gastrin for lung cancer, serun NSE and gastrin were measured with ABC ELISA and Radioimmunoassay in 30 healthy persons(C),25 patients with benign pulmonary diseased (BPD),55 patients with non small cell lung cancer (NSCLC) and 15 patients with small cell lung cancer(SCLC). The results revealed that serum concentrations of NSE and gastrin had significant differences in the four groups (P<0.001).The mean values of NSE and gastrin in C,BPD,NSCLC,SCLC were 8.22,10.84,14.64,32.00 μg/L and 59.47,82.00,221.53,356.84 ng/L,respectively. If values above 20.3 μg/L(NSE) and 81.4 ng/L (gastrin) were considered abnormal, the positive rates of NSE and gastrin in SCLC, NSCLC were 80%, 14.54% and 80%, 63.63% respectively. After the patients with lung cancer were treated, serum levels of NSE and gastrin decreased in SCLC significantly (P<0.001),but levels of gastrin decreased only in NSCLC(P<0.001).The results suggest that NSE may be used in diagnosing, histological typing and therapy monitoring in SCLC,and gastrin in various lung cancer. Combined determinations of NSE and gastrin may raise their value in clinical use.

关键词(KeyWords): 肺,癌,神经元特异性烯醇酶,胃泌素类
lung;carcinoma ;neuron specific enolase; gastrins

Abstract:

Keywords:

基金项目(Foundation): 贵州省卫生厅科研基金

作者(Author): 周建奖,王仁敏,润丹
Zhou Jianjiang, et al Guizhou Institute of Tumour Prevention and Cure

Email:

DOI: 10.19367/j.cnki.1000-2707.1998.03.019

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