贵州医科大学学报

2016, v.41;No.185(02) 150-154

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肝细胞癌中胰岛素样生长因子1受体的表达及意义
The Significance of Insulin-like Growth Factor 1 Receptor Expression in Hepatocellular Carcinoma

余梦懿;成元华;申九妹;孙博;
YU Mengyi;CHENG Yuanhua;SHEN Jiumei;SUN Bo;Department of Pathology,Guizhou Medical University;Department of Pathology,Traditional Chinese Medicine Hospital;Guizhou Medical University;

摘要(Abstract):

目的:探讨胰岛素样生长因子1受体(IGF-1R)在肝细胞癌(HCC)中的表达及意义。方法:采用免疫组织化学En Vision两步法检测HCC病例癌组织及配对癌旁组织中IGF-1R的蛋白表达,分析IGF-1R表达水平与HCC患者临床病理特征及微血管密度(MVD)的关系,同时随访观察不同IGF-1R表达水平或MVD计数HCC患者的复发、转移及死亡率。结果:HCC癌组织中IGF-1R蛋白表达水平高于癌旁组织,差异有统计学意义(P<0.05);IGF-1R高表达的HCC中,有血管浸润、病理分级Ⅲ~Ⅳ级、临床TNMⅡ~Ⅲ期患者人数多于IGF-1R低表达人数(P<0.05);癌组织中MVD值明显高于癌旁组织,差异有统计学意义(P<0.001);经Spearman等级相关分析显示IGF-1R蛋白表达水平与MVD计数呈正相关,IGF-1R高表达及MVD计数较高的HCC患者复发、转移及死亡率也较高(P<0.05)。结论:IGF-1R可促进HCC的复发、转移,与促进肿瘤血管新生有关。
Objective: To investigate the expression of insulin-like growth factor 1 receptor( IGF-1R) and the relationship between IGF-1R and the clinicopathologic features in hepatocellular carcinoma( HCC). Methods:Immunohistochemical Envision method was utilized to detect the expression of IGF-1R. MVD was marked by antibody CD34 and counted. The follow-up data of the cases of HCC was analyzed by Kaplan-Merier method for survival with log-rank test. Result:(1) The IGF-1R protein showed a higher expression in HCC than in the tumor-adjacent tissues,the difference was statistically significant( P < 0. 05).(2) The difference of the number of IGF-1R protein overexpression in histological grade and TNM stage was significant( P < 0. 05),moreover,the vascular infiltration group was significantly more than group without vascular invasion( P < 0. 05). But there was no significant difference between different tumor size,different gender,age,alcohol intake history,HBs Ag,AFP,tumor number and with or without liver cirrhosis( P > 0. 05).(3) The value of MVD was higher in HCC than that in tumor-adjacent tissues( P < 0. 05).(4) By Spearman rank correlation analysis,the level of MVD was positively correlated with IGF-1R protein expression.(5) By survival analysis of the 38 cases of HCC with follow-up data,the difference in terms of the rate of recurrence,metastasis and survival rate between the group of the high and low expression of IGF-1R protein was significant( P < 0. 05).Conclusion:IGF-1R protein may promote the occurrence and development of HCC,and promote the neovasculation in HCC. The expression of IGF-1Rcan be used as a marker to evaluate the prognosis of HCC.

关键词(KeyWords): 癌,肝细胞;胰岛素样生长因子1受体;免疫组织化学;微血管密度;基因表达
carcinoma;hepatocellular;insulin-like growth factor 1 receptor;immunohistochemistry;vessel density;gene expression

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基金项目(Foundation): 贵州省科学技术基金[黔科合J字KLG(2013)27号];贵州省科学技术基金[黔科合J字(2009)2187号];; 贵州省科技计划项目[黔科合SY字(2011)3062号];; 贵阳市科学技术计划项目[(2009)筑科农合同字第3-020号]

作者(Author): 余梦懿;成元华;申九妹;孙博;
YU Mengyi;CHENG Yuanhua;SHEN Jiumei;SUN Bo;Department of Pathology,Guizhou Medical University;Department of Pathology,Traditional Chinese Medicine Hospital;Guizhou Medical University;

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DOI: 10.19367/j.cnki.1000-2707.2016.02.007

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