贵州医科大学学报

1985, (03) 167-170

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84001浸膏抗精子发生的研究
A STUDY OF THE ANTISPERMATOGENESIS OF 84001 FRUIT EXTRACT

覃国芳;何清华;王文潮;
Qin Guofang, He Qinghua, Wang Wenchao Dep. of Histol and Embryol

摘要(Abstract):

<正> 84001含有避孕成分,对生精细胞有抑制作用。国外利用类似植物进行试验,也证实有相同效果。我们选用58只雄性小白鼠作试验,共分四组,其中2组分别给84001浸膏(3.3ml/kg/日和2ml/kg/日)连续24天后,以1:2与雌鼠交配。结果前组母鼠100%未孕,后组有95%未孕;二组雄鼠睾丸比对照组为小,曲细精管部分萎缩,管腔内有异常的精子细胞和多核巨噬细胞。支持细胞和间质细胞在形态上来显示异常。材料与方法选用雄性小鼠58只随机分为四组;2个实验组分别给3.3ml/kg和2ml/kg84001浸膏;另二组一组每日给普通饮用
The purpose of the present study is to consider the action of 84001 (a kind of fruit extract) for male anti-fertility. The experimental animals we used, were albino mice, The male mice were divided into 4 groups. Two groups were administrated orally with 84001 of daily dose 3.3ml/kg and 2ml/kg respectively for 24 days then the animals were copulated with females at the ratio of 1: 2. In comparison with the controls, the testicular size of the 2 experimental groups became just a little smaller and their weight lower. Histologically, in the atrophic seminiferous tubules, the spermatogenous cells are impaired in verious degrees and the abnomal spermatids and giant multinucleated cells are not uncommon. There is no apparent morphological change with Leydig and sustentacular cells. The results are in the 3.3ml/kg group appears 100% infertility whil 2ml/kg group 95%. So that the action of 84001 for male anti-fertility is obvious.

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作者(Author): 覃国芳;何清华;王文潮;
Qin Guofang, He Qinghua, Wang Wenchao Dep. of Histol and Embryol

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DOI: 10.19367/j.cnki.1000-2707.1985.03.003

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