唐斌,何常
TANG Bin,HE Chang(Department of Pathology

• 1:贵阳医学院病理学教研室
• 2:贵阳医学院

摘要(Abstract)：

目的:探讨TIP30蛋白在结直肠癌中的表达及其意义。方法:采用S-P免疫组织化学染色法检测58例结直肠癌组织及20例结直肠黏膜慢性炎症组织中TIP30蛋白表达。结果:TIP30蛋白在结直肠癌组织中的阳性表达率为36.20%(21/58),显著低于慢性炎症组的95%(19/20),差异有显著性(P<0.01);TIP30蛋白在结直肠癌中的表达与淋巴结转移(P<0.05)、浸润程度(P<0.05)及预后(P<0.05)有关。结论:TIP30的表达在结直肠癌中的发生、发展及预后中可能扮演着重要的角色。
Objective: To investigate expression of tat interacting protein 30(TIP30) in colorectal carcinoma and to explore the clinical significance.Methods: The expression of TIP30 protein in 58 specimens of colorectal carcinoma and 20 specimens of colorectal inflammatory tissue was detected with SP immunohistochemistry method.Results: The positive rate of TIP30 was 36.20%(21/58) in colorectal carcinoma,which was significantly lower than that of 95%(19/20) in colorectal inflammatory tissue(P<0.01).The expression of TIP30 protein in colorectal carcinoma related to lymph metastasis(P<0.05),and infiltration degree(P<0.05),and influenced prognosis of the disease(P<0.05).Conclusions: TIP30 protein may play an important role in the occurrence,development and prognosis of colorectal carcinoma.

关键词(KeyWords)： 结直肠肿瘤;癌;TIP30;免疫组织化学
colorectal neoplasms;carcinoma;TIP30;immunohistochemistry

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 唐斌,何常
TANG Bin,HE Chang(Department of Pathology

DOI: 10.19367/j.cnki.1000-2707.2010.06.017

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