贵州医科大学学报

2017, v.42;No.207(12) 1436-1438+1442

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贵阳市某医院产超广谱β-内酰胺酶大肠埃希菌的耐药性分析
Drug Resistance of Escherichia Coli Producing Extended Spectrum Beta Lactamase

陈云芬;余俊;陈芳;闵祥;蒲方华;宋伟章;
CHEN Yunfen;YU Jun;CHEN Fang;MIN Xiang;PU Fanghua;SONG Weizhang;Guiyang Sixth Hospital Limited Company;

摘要(Abstract):

目的:分析贵阳市某医院临床分离的产超广谱β内酰胺酶(ESBLs)大肠埃希菌的耐药现状。方法:从贵阳市某医院住院患者痰标本中分离的大肠埃希菌74株,按是否产ESBLs分为产ESBLs菌株和非产ESBLs菌株,比较两组菌株对氨苄西林、氨曲南、头孢他啶、头孢噻肟等常用抗菌素的耐药性。结果:产ESBLs大肠埃希菌对氨曲南、未含酶抑制剂的头孢类抗生素耐药率为100%,对碳青霉烯类、阿米卡星、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦的耐药率为0~2.4%;产ESBLs大肠埃希菌对大多数临床常用抗菌药物耐药率明显高于非产ESBLs大肠埃希菌,差异有统计学意义(P<0.05)。结论:产ESBLs大肠埃希菌感染的患者可首先选用含β-内酰胺酶抑制剂类抗菌药物,重症患者可选用碳青霉烯类抗生素。
Objective: To analyze the drug resistance of ESBLs Escherichia coli of clinical separation in a hospital in Guiyang. Methods: 74 strains of Escherichia coli isolated from the sputum specimens in a hospital of Guiyang were isolated. Whether ESBLs was produced as ESBLs producing strain and producing non ESBLs strain,the drug resistance of two groups to the common antibiotics of ampicillin,amamethoni,ceftazidime and cefotaxime was compared. Results: The drug resistance rate of Escherichia coli producing ESBLs to aztreonam and cephalosporins without enzyme inhibitors was 100%,and the drug resistance rate of carbapenems,Amikacin,piperacillin/tazobactam,and Cefoperazone/sulbactam was 0 ~ 2. 4%. The drug resistance rate of Escherichia coli producing ESBLs to most commonly used antibiotics was significantly higher than that of Escherichia coli producing non ESBLs. Differences were statistically significant( P < 0. 05). Conclusion: The first selection of antibiotics containing beta lactamase inhibitors can be used in patients with infection of ESBLs Escherichia coli,and carbapenems can be used in severe patients.

关键词(KeyWords): 大肠埃希菌;β内酰胺酶;微生物;耐药性;抗生素
Escherichia coli;spectrum β lactamases;microorganism;drug resistance;antibiotic

Abstract:

Keywords:

基金项目(Foundation): 贵阳市卫生和计划生育委员会科学技术计划项目[(2014)筑卫计科技合同字第008号]

作者(Author): 陈云芬;余俊;陈芳;闵祥;蒲方华;宋伟章;
CHEN Yunfen;YU Jun;CHEN Fang;MIN Xiang;PU Fanghua;SONG Weizhang;Guiyang Sixth Hospital Limited Company;

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DOI: 10.19367/j.cnki.1000-2707.2017.12.016

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