赵萍,龚玲,杜立,付蓉,柴雪梅
ZHAO Ping; GONG Ling; DU Li; FU Rong; CHAI Xue-mei (The second people’s hospital of Guiyang;

• 1:贵阳市第二人民医院
• 2:贵阳市第二人民医院
• 3:贵阳市第二人民医院
• 4:贵阳市第二人民医院

摘要(Abstract)：

目的:探讨急性脑梗死患者血清神经特异性烯醇化酶(NSE)的含量变化及杏丁对其的影响。方法:观察急性脑梗死患者在发病3d内和治疗1周后血清NSE变化和神经功能缺损评分变化,并观察杏丁对其的影响。结果:急性脑梗死常规治疗组和杏丁组发病2d内血清NSE均高于对照组(P<0.01)。治疗1周后常规治疗组血清NSE含量仍高于对照组(P<0.05),而杏丁组与对照组之间差异无显著性(P>0.05);杏丁组神经功能缺损评分与常规治疗组相比差异有显著性(P<0.05)。结论:急性脑梗死患者血清NSE含量增高,而杏丁可显著降低NSE的含量;杏丁的近期临床疗效也优于常规治疗组。表明杏丁对急性脑梗死患者具有脑保护作用。
Objective: To investigate the variation of serum content of nerve specific enolase (NSE) in patients with acute cerebral infarction (ACI) and the influence of xingding on it. Methods: To observe the changes of NSE content in serum and nerve function deficit score of patients with ACI in the first 3 days of the onset and one week post-treatment. The results of patients in Xingding treated group (XG) were compared with those of patients in routine treated group (RG). 30 healthy people were chosen as control group. Results: NSE contents of patients in both XG group and RG group in the first 2 days were higher than those of control group ( P< 0.01). In one week post-treatment, NSE content of patients in RG group was still higher than that of control group ( P< 0.05), while that of XG group decreased to the level of control group ( P >0.05), and the nerve function deficit score of XG group was significantly different from that of control group. Conclusions: The NSE content in serum increases in patients with ACI. Xingding can decrease its level. Xingding gives better curative results than routine therapy in a short period, which shows that Xingding has protective effect to brain.

关键词(KeyWords)： 脑梗塞;二裂银杏;磷酸丙酮酸水合酶;神经特异性烯醇化酶;杏丁
brain injuries; ginkgo biloba; phosphophruvate hydratase; nerve specific enolase; xingding

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 赵萍,龚玲,杜立,付蓉,柴雪梅
ZHAO Ping; GONG Ling; DU Li; FU Rong; CHAI Xue-mei (The second people’s hospital of Guiyang;

DOI: 10.19367/j.cnki.1000-2707.2005.03.013

参考文献(References)：

• [1]Barone Fc,Clarj RK,Price WJ,et al.Neuron specific enolase increase in cerebral and systemic circulation fol-lowing focal ischemia[J].Brain Res,1993,623:7.
• [2]王维治.神经病学[M].第四版.北京:人民卫生出版社,2001.130-142
• [3]刘学伍,迟兆富,尚伟,等.癫痫持续状态血与脑脊液神经元特异性烯醇化酶含量的变化及Mg2+的脑保护作用[J].中风与神经疾病杂志,2003,20(2):78-81.

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