贵州医科大学学报

2016, v.41;No.186(03) 307-309

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程序性死亡4基因和5基因在卵巢上皮性癌中的表达
Expression of Apoptosis Related PDCD5 Gene and PDCD4 Gene in Ovarian Cancer

潘玲;何常;
PAN Lin;HE Chang;Department of Pathology,Affiliated Hospital of Guizhou Medical University;

摘要(Abstract):

目的:探讨程序性死亡4基因(PDCD4)、5基因(PDCD5)蛋白在卵巢上皮性癌组织中的表达。方法:113例卵巢上皮性癌患者,根据国际妇产科联盟(FIGO)标准分为Ⅰ期42例、Ⅱ期28例、Ⅲ期30例及Ⅳ期13例,应用免疫组化Envision法检测所有上皮性癌组织、40例卵巢囊腺瘤组织及20例正常卵巢组织中的PDCD4、PDCD5蛋白的表达阳性率,比较2种蛋白表达阳性率在不同FIGO分期的卵巢上皮性癌组织、卵巢囊腺瘤组织及正常卵巢组织的表达。结果:卵巢上皮性癌组织中PDCD4、PDCD5蛋白表达阳性率明显低于卵巢囊腺瘤和正常卵巢组织(P<0.05);PDCD4、PDCD5蛋白在卵巢上皮性癌组织Ⅰ期、Ⅱ期、Ⅲ期及Ⅳ期癌组织中的表达阳性率逐渐降低,差异有统计学意义(P<0.05)。结论:卵巢上皮性癌的发生、发展与PDCD4、PDCD5蛋白表达降低有关。
Objective: To investigate the PDCD4 and PDCD5 expression in epithelial ovarian cancer and its clinical significance. Methods: Adopting envision immunohistochemical detection of 113 patients with ovarian cancer( 42 Phase Ⅰ,28 Phase Ⅱ,30 Phase Ⅲ and 13 phase Ⅳ according to FIGO standard) and 20 normal ovarian tissue in 40 cases of ovarian cyst adenoma and expression positive rate of PDCD4 and PDCD5,comparing expression condition of expression positive rate of both proteins on various FIGO phases epithelial ovarian cancer tissue,ovarian cystadenoma tissue and healthy ovarian tissue. Results: PDCD4 and PDCD5 protein expression positive rate of epithelial ovarian cancer were obviously lower than ovarian cystadenoma and healthy ovarian tissue( P < 0. 05); PDCD4 and PDCD5 protein expression positive rate in epithelial ovarian cancer tissue phase Ⅰ,phase Ⅱ,phaseⅢ and phase Ⅳ cancer tissue were gradually decreasing,differences were statistical significant( P <0. 05). Conclusion: Decreasing of PDCD4 and PDCD5 protein expression in epithelial ovarian cancer is closely related to the occurrence and development of ovarian cancer.

关键词(KeyWords): 程序性死亡;卵巢肿瘤,上皮性;免疫组织化学;染色法;基因表达
apoptosis;ovarian tumor,epithelial;immunohistochemistry;staining method;gene expression

Abstract:

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基金项目(Foundation): 贵州省科技厅基金(E2010-4)

作者(Author): 潘玲;何常;
PAN Lin;HE Chang;Department of Pathology,Affiliated Hospital of Guizhou Medical University;

Email:

DOI: 10.19367/j.cnki.1000-2707.2016.03.016

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