妊娠期下生殖道人乳头状瘤病毒感染及基因分型
訾聃,杨英捷,任念
摘要(Abstract):
目的:了解妊娠期妇女下生殖道人乳头瘤病毒(HPV)感染及基因分型。方法:用核酸分子快速导流杂交基因分型技术检测60例妊娠期妇女宫颈脱落细胞中HPV的表达及基因分型,同时以60例非妊娠期妇女作为对照。结果:60例非妊娠期妇女中HPV感染率为26.67%(16/60),检出高危基因型(HPVl6/18/31/45/52/56型)14例,低危基因型(HPV6/11型)2例,常见亚型(HPV53)2例;60例妊娠期妇女感染率为56.67%(34/60),检出高危基因型(HPVl6/18/31/39/45/52/56/58型)19例,低危基因型(HPV6/1l型)12例,常见亚型(HPV53/66/CP8304)4例,有多重型感染患者。结论:妊娠期HPV感染率明显高于非妊娠期妇女,其中高危亚型以HPVl6/18/52型常见,低危亚型以HPV6/11型常见,应引起临床重视。
关键词(KeyWords):
乳头状瘤病毒,人;妊娠并发症,感染性;基因型
基金项目(Foundation): 贵州省卫生厅基金gzwkj2008-1-012
作者(Author):
訾聃,杨英捷,任念
DOI: 10.19367/j.cnki.1000-2707.2011.05.023
参考文献(References):
- [1]Cox JT.Human papillomavirus testing in primary cervicalscreening and abnormal papanieolaou management[J].Obstet Gynecol Surv,2006(6):15-25.
- [2]Ziegler A,Kastner C,Chng-Claude J.Analysis of preg-naaey and other faglora on detection of human papillomavirus(HPV)infectionusing weighted estimating equationsfor follow-up data[J].StarMed,2003(13):2217-2233.
- [3]王佐,张敏鸣,林晓华,等.妊娠期与非妊娠期人乳头瘤病毒的感染率比较[J].现代妇产科进展,2008(17):6.
- [4]Garozzo G,Nuciforo G,Rocchi CM,et al.Buschke-Lowen-stein tumor in pregnancy[J].European Journal of Obstet-rics,Gynecology and Reproductive Biology,2003(1):88-90.
- [5]程晓东,谢幸.女性生殖道人乳头瘤病毒感染的流行病学[J].实用妇产科杂志,2004(2):65.
- [6]Morales-Peza N,Auewajakul P,Juarez V,et al.Invivotis-sue-specific regulation of the human papillomavivus type-18 eaely promoter by estr-ogen,progesterone,and their an-tagonista[J].Virology,2002(294):135.
- [7]Rintais MA,Grenman SE,Puranen NH,et al.Transmins-sion of high-risk human papillomavivus(HPV)betweenparent and infant:a prospective study of HPV in familiesin Finland[J].J Clin Microbiol,2005(1):376-381.
- [8]周月娣,黄亚娟.妊娠与人乳头瘤病毒感染及其处理[J].上海交通大学学报,2006(12):1411-1413.
文章评论(Comment):
|
||||||||||||||||||
|