贵州医科大学学报

2018, v.43;No.212(05) 568-571

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接头蛋白Crk Ⅰ在喉鳞癌中的表达及意义
Expression and Significance of Crk Ⅰ in Laryngeal Squamous Cell Carcinoma

于明;姚芝芬;龚正鹏;
YU Ming;YAO Zhifen;GONG Zhengpeng;Department of Otorhinolaryngology Head and Neck Surgery,the Affiliated Baiyun Hospital of Guizhou Medical University;Department of Otorhinolaryngology Head and Neck Surgery,the Affiliated Guizhou Medical University;

摘要(Abstract):

目的:探讨接头蛋白Crk Ⅰ在喉鳞癌组织中的表达及意义;方法:采用免疫组化SP法,对54例喉鳞癌手术切除标本和22例癌旁正常组织进行检测,观察Crk Ⅰ在2种组织中的表达,分析Crk Ⅰ的表达与鳞癌临床分期、病理分级、肿瘤转移及生存时间的关系。结果:Crk Ⅰ在喉癌组织中主要表达于细胞质、细胞核可见少量表达、阳性率达64.8%,在癌旁正常组织中少量表达或无表达,2种组织中Crk Ⅰ表达阳性率比较,差异有统计学意义(χ~2=24.149,P<0.01);喉鳞癌组织中,有淋巴结转移者Crk Ⅰ蛋白阳性表达率为91.7%,与无淋巴结转移者的54.8%比较,差异有统计学意义(P<0.05);但Crk Ⅰ蛋白的阳性表达率在各年龄组、不同临床分期、病理分级及不同预后的喉鳞癌患者中比较差异无统计学意义(P>0.05)。结论:接头蛋白Crk Ⅰ可能在喉鳞癌细胞的发生、发展和转移中有重要意义。
Objective: To investigate the expression and significance of Crk Ⅰ in laryngeal squamous cell carcinoma. Methods: Fifty-four cases with laryngeal cancer were detected by immunohistochemistry S-P method and the ablated laryngeal squamous cell carcinoma samples and the normal para-carcinoma tissues were analyzed. Results: Analysis showed that the expression of Crk Ⅰgene in laryngeal squamous cell carcinoma was up-regulated. The difference of Crk Ⅰin the tissues and laryngeal carcinoma of the control group was statistically significant. There was significant difference in lymph node metastasis. Conclusion: Over-expression of Crk Ⅰmay play an important role in the oncogenesis,progression and metastasis of laryngeal carcinoma.

关键词(KeyWords): 喉鳞癌;接头蛋白Crk Ⅰ;免疫组织化学染色;肿瘤;病理分级;基因表达
laryngeal squamous cell carcinoma;Crk Ⅰ;immunohistochemistry;neoplasms;pathological grading;gene expression

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作者(Author): 于明;姚芝芬;龚正鹏;
YU Ming;YAO Zhifen;GONG Zhengpeng;Department of Otorhinolaryngology Head and Neck Surgery,the Affiliated Baiyun Hospital of Guizhou Medical University;Department of Otorhinolaryngology Head and Neck Surgery,the Affiliated Guizhou Medical University;

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DOI: 10.19367/j.cnki.1000-2707.2018.05.015

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