贵州医科大学学报

2018, v.43;No.213(06) 730-733

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胚胎植入前遗传学筛查技术在复发性流产中的应用
Application of Preimplantation Genetic Screening in Recurrent Spontaneous Abortion

肖育红;
XIAO Yuhong;ShenYang 202 Hospital of PLA Eugenics Center;

摘要(Abstract):

目的:探讨胚胎植入前遗传学筛查技术在复发性流产中的应用价值。方法:将53例复发性流产患者随机分为对照组19例和观察组34例,对照组采用常规体外受精-胚胎移植,观察组在体外受精后对胚胎进行高通量测序胚胎植入前遗传学筛查,分析观察组患者高通量测序PGS检出染色体整倍体囊胚和非整倍体囊胚数量,比较观察组和对照组患者的胚胎着床率和早期流产率。结果:观察组复发性流产患者共取76枚胚胎,高通量测序PGS共检出染色体整倍囊胚37枚(48.68%),非整倍体囊胚39枚(51.32%);观察组胚胎着床率明显高于对照组,而早期流产率较对照组低,组间比较差异有统计学意义(P<0.05)。结论:高通量测序胚胎植入前遗传学筛查整倍体囊胚,可增加复发性流产患者胚胎着床率,同时降低早期流产率。
Objective: To investigate the value of preimplantation genetic screening in recurrent spontaneous abortion( RSA). Methods: 53 patients with RSA treated in our hospital from December 1,2015 to December 1,2017 were selected and randomly divided into two groups according to the principle of informed consent. 19 cases in the control group was treated with conventional in vitro fertilization and embryo transfer( IVF-ET) procedures,while 34 cases in the observation group underwent preimplantation genetic screening for high throughput sequencing embryos after in vitro fertilization. Then the high-throughput sequencing results and clinical pregnancy outcomes of the two groups were analyzed.Results: A total of 37 euploid blastocysts( 48. 68%) were detected by high-throughput preimplantation genetic screening,and 39 aneuploid blastocysts( 51. 32%) were detected. The embryo implantation rate in the observation group was significantly higher than that in the control group( 67. 65% vs36. 84%); The early abortion rate in the observation group was lower than that of the control group( 4. 35% vs 42. 85%),and the difference between the two groups was significant( P < 0. 05). Conclusion: High-throughput sequencing preimplantation genetic screening of euploid blastocysts can increase the embryo implantation rate in patients with RSA and reduce the early abortion rate,which can be used as a way to avoid recurrent miscarriage in patients with pregnancy defective birth.

关键词(KeyWords): 高通量测序;胚胎植入;遗传学筛查技术;复发性流产;着床率
high-throughput sequencing;preimplantation;genetic screening;recurrent spontaneous abortion;implantation rate

Abstract:

Keywords:

基金项目(Foundation): 辽宁省自然科学基金项目资助(201602754)

作者(Author): 肖育红;
XIAO Yuhong;ShenYang 202 Hospital of PLA Eugenics Center;

Email:

DOI: 10.19367/j.cnki.1000-2707.2018.06.024

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