贵州医科大学学报

2013, v.38;No.163(04) 351-355

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紫金透骨喷雾剂经皮肤给药对家兔的长期毒性
A Study on Long-term Toxicity of Zijin-Speranskia Spray in Rabbits

周雯;李月婷;董莉;肖婷婷;李美珍;兰燕宇;王永林;
ZHOU Wen;LI Yueting;DONG Li;XIAO Tingting;LI Meizhen;LAN Yanyu;WANG Yonglin;School of Pharmacology,Guiyang Medical College;

摘要(Abstract):

目的:观察紫金透骨喷雾剂对家兔的长期毒性。方法:将80只家兔随机分为4组,紫金透骨喷雾剂高、中、低剂量组(按生药量计为3.0,1.50,0.75 g/kg)及对照组(70%乙醇)每组20只,经家兔皮肤给药,每天1次,连续用药4周,停药后观察2周,观察给药4周和停药2周家兔的一般状况,称量家兔体重,计算主要脏器的脏器系数,检测血液学、血液生物化学指标及病理组织变化。结果:各给药组家兔的一般状况未见明显异常,血液学指标、生化指标及主要脏器重量系数等均未见异常,与空白对照组比较无统计学差异;主要脏器也未见异常病理改变。结论:紫金透骨喷雾剂在临床剂量范围内经皮肤给药长期使用安全。
Objective: To observe the long-term toxicity of Zijin-Speranskia spray(ZS) in rabbits.Methods: Eighty Rabbits were randomly divided into 4 groups,with 20 in each.They were ZS treated groups at high,medium,and low doses(groups H,M,and L) and control group(group C).ZS was given by dermal administration at doses of 3.0,1.50,0.75g /(kg·d) respectively for 4 weeks,and rabbits in group C were given normal saline instead.General conditions of the animals were observed consecutively until 2 weeks after the drug was stopped.At the end of the experiment,parameters of body weight,hematology,hematological biochemics,organ / body weight ratio and pathohistology were detected.Results: General conditions of experimental Rabbits did not change,and the results of all detections were normal.There was no significant difference between ZS treated groups and control group.Conclusion: ZS spray is safe for dermal administration in clinical long-term use.

关键词(KeyWords): 紫金透骨喷雾剂;药物毒性;兔
Zijintougu spray;drug toxicity;rabbit

Abstract:

Keywords:

基金项目(Foundation): 贵州省中药现代化科技产业研究开发专项基金项目:黔科合中药字[2011]508号、黔科合中药专字[2007]5016号;; 贵州省科技厅科技计划项目:黔科合计工字[2009]4001;; 贵阳市科学技术计划项目:[2009]筑科中合同字第9-3-04号;; 贵州省科技厅创新人才团队专项基金项目

作者(Author): 周雯;李月婷;董莉;肖婷婷;李美珍;兰燕宇;王永林;
ZHOU Wen;LI Yueting;DONG Li;XIAO Tingting;LI Meizhen;LAN Yanyu;WANG Yonglin;School of Pharmacology,Guiyang Medical College;

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DOI: 10.19367/j.cnki.1000-2707.2013.04.006

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