盐酸帕洛诺司琼预防化疗引起的延迟性呕吐
贾青青,孙长江,喻杰
摘要(Abstract)：
目的:观察盐酸帕洛诺司琼预防化疗引起的延迟性呕吐的临床疗效。方法:将45例接受顺铂联合化疗的患者随机分为试验组和对照组,分别给予盐酸帕洛诺司琼0.25 mg静脉推注、托烷司琼6 mg静脉滴注,根据恶心、呕吐的控制情况评价疗效。结果:试验组和对照组对急性恶心的有效率分别为86.4%和82.6%,对急性呕吐的有效率分别为90.9%和82.6%,两组的有效率比较无统计学意义;对延迟性恶心的有效率为63.6%和34.8%,对延迟性呕吐的有效率为72.7%和47.8%,试验组优于对照组,P<0.05。结论:盐酸帕洛诺司琼和托烷司琼对急性及延迟性恶心、呕吐均有效,但预防延迟性恶心、呕吐,盐酸帕洛诺司琼的效果优于托烷司琼。
关键词(KeyWords)：
帕洛诺司琼;托烷司琼;化学疗法;恶心;呕吐;肿瘤
基金项目(Foundation):
作者(Author):
贾青青,孙长江,喻杰
DOI: 10.19367/j.cnki.1000-2707.2010.06.022
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