刘飞,鲍锋
LIU Fei, BAO Feng(Anshun Institute for Drug Inspection, Guizhou Province, Anshun 561000, China)

• 1:安顺市药品检验所
• 2:安顺市药品检验所 贵州安顺561000
• 3:贵州安顺561000

摘要(Abstract)：

目的:研究制定肌苷片溶出度测定的方法。方法:采取转篮法,以0.01 mol/LHC l溶液为介质,转速为50r/m in,紫外分光光度法在248 nm波长处测定吸收度。结果:30 m in时的溶出量不少于标示量的75%,在6.8²0.4mg/L范围内呈良好的线性关系,r=0.999 9(n=7)。结论:紫外分光光度法准确可靠,能满足质量控制的要求。
Objective: To find a method for determination of solubility of inosine tablet. Methods: Basker method was adopted. Hydrochloric acid with concentrition of 0.01mol/L was used as solvent. The rotational speed was 50r/min. The absorptivity was recorded with ultraviolet spectrophotometer at 248 nm. Results: The solubility within 30 minutes was not less than 75% of indicated amount, and a good lineal relation was found in the range of 6.820.4mg/L范围内呈良好的线性关系,r=0.999 9(n=7)。结论:紫外分光光度法准确可靠,能满足质量控制的要求。
Objective: To find a method for determination of solubility of inosine tablet. Methods: Basker method was adopted. Hydrochloric acid with concentrition of 0.01mol/L was used as solvent. The rotational speed was 50r/min. The absorptivity was recorded with ultraviolet spectrophotometer at 248 nm. Results: The solubility within 30 minutes was not less than 75% of indicated amount, and a good lineal relation was found in the range of 6.8²0.4mg/L, with r=0.9999(n=7). Conclusion: This method is accurate and reliable, and can meet the need of quality control to inosine.

关键词(KeyWords)： 肌苷;分光光度法,紫外线;溶解度
inosine; spectrophotometry,ultraviolet; solubility

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 刘飞,鲍锋
LIU Fei, BAO Feng(Anshun Institute for Drug Inspection, Guizhou Province, Anshun 561000, China)

DOI: 10.19367/j.cnki.1000-2707.2005.04.013

参考文献(References)：

• [1]中华人民共和国卫生部药典委员会.中华人民共和国卫生部药品标准[S].二部第六册(生化药品第一分册).1998.41.
• [2]高明远,王平,徐灿辉.关于肌苷片含量测定方法的探讨[J].中国药事,2004,2:122.
• [3]国家药典委员会.中华人民共和国药典[S].二部.北京:化学工业出版社,2000.附录75.

文章评论(Comment)：