天参益智方对老年性痴呆大鼠学习记忆能力的影响Influence of Tianshenyizhi Recipe on Learning-memory Ability of Senil Dementia Mice
罗喜荣,罗小美,郝晓燕,罗俊
LUO Xirong1,LUO Xiaomei2,HAO Xiaoyan1,LUO Jun1(1.Guiyang Medical College
摘要(Abstract)：
目的:观察天参益智方(TSYZ)对慢性铝中毒痴呆模型大鼠的空间探索学习记忆功能的改善作用,并对该中药复方进行最大给药量急性毒性实验研究。方法:以慢性铝中毒法复制痴呆动物模型,随机将动物模型分为5组,即模型组,天参益智方高、中、低剂量组,阳性对照组,另设正常对照组,用水迷宫法对其空间探索学习记忆能力进行检测。结果:慢性铝中毒痴呆模型组大鼠在安全岛象限的搜索时间及搜索距离显著延长,天参益智方高剂量组的搜索时间及搜索距离显著低于模型组。结论:天参益智方对慢性铝中毒痴呆大鼠的学习记忆能力有明显的改善作用,且无明显毒性。
Objective:To observe the improving effects of Tianshenyizhi (TSYZ) recipe on the ability of learning and memory spatially of senil dementia SD mice exposed to AlCl3 ,and to test if TSYZ could cause acute toxicity when maximum dosage of it was used. Methods:Animal model of senil dementia was induced by i.g intaking AlCl3 for long-term. The model mice were divided into 5 groups:model control group (group M),naofukang treated group (group N),and TSYZ treated groups (1.08 g/kg,0.43 g/kg,and 0.22 g/kg respectively). A normal mouse group was also observed. The ability of learning-memory of mice was tested with water maze method. Results:Mean exploring time and mean exploring distance in group M obviously prolonged,and were significantly higher than those in TSYZ treated groups. Conclusion:TSYZ recipe has obvious improving effects on ability of learning and memory of senil dementia mice,and has no remarkable toxicity.
关键词(KeyWords)：
阿尔茨海默病;天参益智方;铝化合物;学习;记忆;大鼠
Alzheimer disease; TSYZ fomula; aluminum compounds; learning; memory; rats
基金项目(Foundation): 贵州省科技厅中药现代化专项资助项目(2004-40)
作者(Author):
罗喜荣,罗小美,郝晓燕,罗俊
LUO Xirong1,LUO Xiaomei2,HAO Xiaoyan1,LUO Jun1(1.Guiyang Medical College
DOI: 10.19367/j.cnki.1000-2707.2010.03.004
参考文献(References)：
- [1]张魁华,赖世隆,王奇,等.补肾益智方对老年性痴呆模型动物定位航行学习记忆功能的改善作用[J].中草药,2002(10):917-920.
- [2]罗喜荣,李红艳,郝小燕,等.天参益智方对老年痴呆模型学习记忆能力及Aβ1-40的影响[J].时珍国医国药,2007(5):1049-1050
- [3]刘晖,陈康远,郑泽荣,等.首灵健脑胶囊对老年性痴呆小鼠学习记忆及脑内微量元素的影响[J].中西医结合心脑血管病杂志,2006(6):503-505.
- [4]刘永琦,何建成,安耀荣,等.扶元补脑冲剂对老年性痴呆鼠脑ATP酶及脂质过氧化反应的影响[J].中成药,2004(2):130-133
- [5]Yokel RA,Provan SD,Meyer JJ,et al.Aluminum intoxica-tion and the victim of Alzheimer’s disease:similarities and differences[J].Neurotoxicology,1988(3):429-442.
- [6]Golloib LG.Behvioral changes in induced by aluminum in drinking water[J].Dementia,1991(5):278-282.
- [7]Yen Koo HC.The effect of aluminum on conditioned a-voidance responce(CAR)in mice[J].Toxicol Ind Health,1992(1-2):1-7.
- [8]白慧梅.中医药治疗老年性痴呆临床研究概况[J].河北中医,2008(6):658-660.
- [9]史志刚,张新华,刘英华,等.复原胶囊治疗老年性痴呆150例的临床研究[J].中华实用中西医杂志,2005(10):1488-1490.
文章评论(Comment)：
|
||||||||||||||||||
|
||||||||||||||||||