贵州医科大学学报

2019, v.44;No.226(07) 830-832+837

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无创呼吸机干预对冠心病合并阻塞性睡眠呼吸暂停低通气综合征患者的疗效
Non-invasive Ventilator Intervention in Newly Diagnosed Coronary Heart Disease Patients with Obstructive Sleep Apnea-hypopnea Syndrome

储新;蒋小涵;王虎;刘晓桥;杨永曜;
CHU Xin;JIANG Xiaohan;WANG Hu;LIU Xiaoqiao;YANG Yongyao;Department of Internal Medicine-Cadiovascular,People's Hospital Affiliated to Guizhou Medical University;Guizhou Medical University;People's Hospital of Guizhou Province,Guizhou Medical University;

摘要(Abstract):

目的:探讨无创呼吸机治疗初诊冠状动脉粥样硬化性心脏病(CHD)合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的效果。方法:初诊CHD合并OSAHS的70例患者随机均分为对照组和观察组,对照组给予常规基础治疗,观察组在常规治疗的基础上联合无创呼吸机治疗;分析并记录两组患者的入院前后睡眠呼吸暂停低通气指数(AHI)、夜间最低血氧饱和度(Sa O2)、平均夜间呼吸暂停时间(T)、心功能B型脑钠肽(BNP)、左室射血分数(LVEF)及夜间平均心率(HR)。结果:对照组心率较治疗前显著改善,观察组AHI、Sa O2、BNP及HR指较治疗前均有显著改善,同时观察组AHI、Sa O2、BNP及HR的改善情况优于对照组,差异有统计学意义(P<0.05);观察组LVEF较治疗前有所改善,但与对照组比较差异无统计学意义(P>0.05)。结论:初诊CHD并OSAHS患者进行无创呼吸机治疗,不仅能改善患者的低通气,并且有助于改善患者的心功能状况。
Objective:To investigate the effect of non-invasive ventilator on patients with newly diagnosed coronary heart disease(CHD) complicated with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods:Seventy patients with SCHD-OSAHS were randomly divided into two groups:the control group(given routine basic therapy) and the observation group(given routine basic therapy,combined non-invasive ventilator treatment),n = 35 in each group.Comparisons of the sleep apnea hypopnea index(AHI),the lowest nocturnal oxygen saturation(SaO2),the average nocturnal apnea time(T) and B-type natriuretic peptide(BNP) left ventricular ejection fractions(LVEF) and heart rate(HR) at night of the two groups were performed before and after the treatment in the hospital.Results:After treatment,the HR of the control group was significantly improved compared with that before treatment(P<0.05).The AHI,SaO2,T,BNP and LVEF(P>0.05) of the observation group were significantly improved than before treatment(P<0.05).And the AHI,SaO2,BNP,HR of the observation group were obviously better than those in control group,and the difference was statistically significant(P<0.05).The LVEF of the observation group was significantly improved compared with that before treatment.But,compared with the control group there is no statistical significance(P>0.05).Conclusion:Non-invasive ventilator treatment of patients with newly diagnosed CHD and OSAHS can not only improve the hypopnea status,but also improve the patients ' cardiac function.It is effective in the clinical application.

关键词(KeyWords): 冠心病;阻塞性睡眠呼吸暂停低通气综合征;无创呼吸机
coronary heart disease;obstructive sleep apnea-hypopnea syndrome;non-invasive ventilator

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(81660080);; 国家临床重点专科建设项目[(2013)544];; 贵州省科学技术厅临床研究中心项目[黔科合平台人才(2017)5405]

作者(Author): 储新;蒋小涵;王虎;刘晓桥;杨永曜;
CHU Xin;JIANG Xiaohan;WANG Hu;LIU Xiaoqiao;YANG Yongyao;Department of Internal Medicine-Cadiovascular,People's Hospital Affiliated to Guizhou Medical University;Guizhou Medical University;People's Hospital of Guizhou Province,Guizhou Medical University;

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DOI: 10.19367/j.cnki.1000-2707.2019.07.017

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