贵州医科大学学报

2011, v.36;No.153(06) 554-557

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人乳头瘤病毒16型在宫颈上皮内瘤变和宫颈浸润癌中的感染状态
Infection Status of Human Papillomavirus(HPV) Type 16 in Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer

朱燕;杨英捷;宋鸿碧;
ZHU Yan,YANG Yingjie,SONG Hongbi (Department of Obstetrics and Gynecology,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:探讨人乳头状瘤病毒(human papillomavirus,HPV)16型在宫颈上皮内瘤变(cervical intraepi-thelial neoplasia,CIN)和宫颈浸润癌患者中的感染状态。方法:分别采用免疫组织化学(immunohistochemistry,IHC)方法及核酸分子快速导流杂交基因芯片技术(DNA flow-through hybridization gene chip technique,HybriMax)检测30例CIN和33例宫颈浸润癌患者的HPV16型感染状态。结果:IHC技术中63例患者HPV16总感染率为34.92%(22/63),CIN33.33%(10/30),宫颈浸润癌36.36%(12/33);HybriMax技术中63例患者HPV16总感染率为28.57%(18/63),CIN 23.33%(7/30),宫颈浸润癌33.33%(11/33)。结论:本组资料的CIN和宫颈浸润癌HPV16感染率低于其他地区的相关报道,提示CIN和宫颈浸润癌的发生可能存在其他原因。
Objective: To investigate the infection status of human papillomavirus type 16(HPV16) in cervical intraepithelial neoplasia(CIN) and invasive cervical cancer(ICC).Methods: Immunohistochemistry(IHC)and DNA flow-through hybridization gene chip technique(HybriMax)were used to detect HPV16 in 30 CIN cases and 33 ICC cases.Results: HPV16 infection rates in total 63 cases,CIN cases and ICC cases were 34.92%(22/63),33.33%(10/30)and 36.36%(12/33) respectively tested with IHC.While these infection rates tested with HybriMax were 28.57%(18/63),23.33%(7/30)and 33.33%(11/33)respectively.Conclusions: The HPV16 infection rates in CIN and ICC cases observed in this investigation are lower than those reported from other regions,suggesting that CIN and ICC in these patients may be caused by other factors.

关键词(KeyWords): 乳头状瘤病毒,人;宫颈上皮内瘤样病变;宫颈肿瘤;免疫组织化学
papillomavirus,human;cervical intraepithelial neoplasia;cervix neoplasms;immunohistochemistry

Abstract:

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基金项目(Foundation): 贵州省科技厅基金资助项目[黔科合J字(2007)2105号]

作者(Author): 朱燕;杨英捷;宋鸿碧;
ZHU Yan,YANG Yingjie,SONG Hongbi (Department of Obstetrics and Gynecology,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2011.06.003

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