吴德丹,毛冬梅,张忠杰,姚旌
WU Dedan,MAO Dongmei,ZHANG Zhongjie,YAO Jing

• 1:贵州医科大学研究生院
• 2:贵州医科大学附院疼痛科

摘要(Abstract)：

目的:观察星状神经节阻滞(SGB)对多器官功能障碍综合征(MODS)家兔血浆P物质(SP)和降钙素基因相关肽(CGRP)水平的影响。方法:成年健康家兔30只,分为MODS组、SGB组和对照组,每组10只;3组家兔麻醉后分离右侧星状神经节,术后第8天MODS组和SGB组采用"二次打击"和腹腔注射内毒素制作家兔MODS模型,SGB组家兔注射内毒素1 h后立即行右侧SGB,对照组家兔仅腹腔注射等剂量生理盐水;分别于失血性休克前(T0)、注射LPS后12 h时(T1)、24 h时(T2)、36 h时(T3)及48 h时(T4)用放射免疫法检测血浆SP、CGRP含量。结果:MODS组和SGB组各时间点血浆SP含量较对照组增加(P<0.05),且MODS组较SGB组升高更明显(P<0.05);MODS组和SGB组各时间点血浆CGRP含量较对照组增加(P<0.05),且MODS组较SGB组升高更明显(P<0.05)。结论:MODS家兔血浆中SP、CGRP增加,SGB能调节SP、CGRP表达,提示SGB对MODS有一定的积极意义。
Objective: To investigate the effects of stellate ganglion block(SGB) on plasma contents of substance P( SP) and calcitonion gene-related peptide( CGRP) in rabbits with multiple organ dysfunction syndrome( MODS). Methods: Thirty rabbits were divided into three groups: MODS model group,SGB treatment group and control group with 10 in each; the right stellate ganglion of three groups rabbits were separated after anesthesia,Second-Strike were adopted on MODS group and SGB group on 8D after operation,and endotoxin intraperitoneal injection was applied to produce rabbits MODS model; rabbits of SGB group were performed with right SGB right after 1 h of endotoxin injection,RIA was adopted to test plasma SP and CGRP content before hemorrhagic shock( TO),12 h after LPS injection( T1),24 h(T2),36 h(T3) and 48 h(T4). Results: Plasma SP content increased at each time point in MODS and SGB groups compared with control group( P < 0. 05),the contents of plasma SP in MODS group increased significantly than SGB group( P < 0. 05); plasma CGRP content increased at each time point in MODS and SGB groups compared with control group( P < 0. 05). Conclusion: The content of SP and CGRP increased in rabbits plasma with MODS,the SGB could regulate expression of SP and CGRP,it is suggested that SGB may play an active role in treatment of MODS.

关键词(KeyWords)： 星状神经节;神经传导阻滞;多器官功能障碍;P物质;降钙素基因相关肽
stellate ganglion block;nerve block;multiple organ dysfunction;P matters;calcitonion gene-related peptide

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技支撑计划项目(S2011SP00203679449)

作者(Author): 吴德丹,毛冬梅,张忠杰,姚旌
WU Dedan,MAO Dongmei,ZHANG Zhongjie,YAO Jing

DOI: 10.19367/j.cnki.1000-2707.2016.02.016

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