贵州医科大学学报

2009, v.34;No.141(06) 655-658

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抑制素B水平及相关因素与卵巢反应性的探讨
An Investigation on Association of Serum Inhibin B Level and Other Relevant Factors with Ovarian Response

徐括琴;周从容;
XU Kuoqin,ZHOU Congrong(The Reproductive Center,Department of Gynaecology and Obstetrics,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:探讨抑制素B(INHB)水平及相关因素与卵巢反应性的关系,寻求预测卵巢反应性的较好指标。方法:收集55例首次接受体外受精/单精子卵胞浆内注射受精-胚胎移植术(IVF/ICSI-ET)治疗的患者,在上次月经周期的第2~4天及降调节后控制性卵巢刺激日分别取血测定INHB、卵泡刺激素(FSH);根据获卵数、注射绒毛膜促性腺激素日雌激素水平、促性腺激素(Gn)用量,将患者分为低反应组、正常反应组、高反应组,比较3组降调节前后INHB及FSH水平、年龄(AGE)、窦卵泡数(antral follicles counts,AFC)、Gn用量、Gn起始剂量,分析卵巢反应性与这些指标的关系。结果:(1)降调节前后的INHB(bINHB、INHBd0)水平、AGE、AFC、Gn用量、Gn起始剂量在3组之间有统计学差异(P<0.05),降调节前后的FSH(bFSH、FSHd0)水平在3组间无统计学差异(P>0.05);(2)获卵数与降调节前后INHB水平、AGE和AFC无相关性,与降调节前后FSH水平呈负相关,降调节FSH水平较基础FSH水平更具统计学意义。结论:降调节前后的INHB水平可能不是预测卵巢反应性的较好指标,降调节前后的FSH水平可能能较好的预测卵巢反应性,且降调节后的FSH水平可能较基础FSH水平更具有临床价值。
Objective:To explore the value of serum inhibin B(INHB)levels and other relevant factors in predicting ovarian response in in vitro fertilization/intracytoplasmic sperm injection fertilization and embryo transfer(IVF/ICSI~ET)cycles,and so as to find better indicators for ovarian response.Methods:A total of 55 patients undergoing IVF were chosen,and their serum INHB and follicle-stimulating hormone(FSH)were detected on day 2~4 of the menstrual cycle and before the first administration of gonadtrophin after the down-regulation.The number of retrieved oocytes(NRO)was calculated.According to NRO and the levels of estrogen(E2)on human chorionic gonadotropin(HCG)administration day,and the total gonadotropin(Gn)dosage used,patients were divided into 3 groups:low response,high response,and normal response.The serum levels of INHB,FSH,antral follicles counts(AFC),Gn dosages used,and the initial doses of Gn of these groups before and after the down-regulation were determined.The data together with patient's age were analyzed statistically with methods of correlation analysis and stepwise linear regression analysis.Results:(1)There were statistically significant differences of INHB levels,age,AFC,Gn dosages,initial doses of Gn before and after the down-regulation among the 3 groups(P<0.05),while no significant difference of FSH level was found(P>0.05);(2)Correlation between NRO and INHB levels,age,AFC,or Gn dosage did not exist,but it was significantly negatively correlated with FSH levels,specially those after down-regulation.Conclusions:INHB levels before or after down-regulation might not be an ideal index reflecting ovarian responses,while FSH levels can forecast ovarian responses better,specially that after down-regulation is more statistically significant.

关键词(KeyWords): 抑制素类;胚胎移植;卵巢功能试验;年龄因素;卵泡
inhibins;embryo transfer;ovarian function tests;age factors;ovarian follicle

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作者(Author): 徐括琴;周从容;
XU Kuoqin,ZHOU Congrong(The Reproductive Center,Department of Gynaecology and Obstetrics,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2009.06.019

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