齐伟静,刘永刚,高爱民,马艳
QI Weijing,LIU Yonggang,GAO Aimin,MA Yan

• 1:保定市第一中心医院神经内科

摘要(Abstract)：

目的:观察养血清脑颗粒对急性脑梗死患者血清同型半胱氨酸及超敏C反应蛋白的影响。方法:100例急性脑梗死患者随机均分为治疗组和对照组,对照组患者采用阿司匹林肠溶片、阿托伐他汀钙片及营养神经、改善循环等治疗,治疗组在对照组基础上加用养血清脑颗粒治疗4周;分别于治疗前及治疗4周时检测两组患者血清同型半胱氨酸(Hcy)及超敏C反应蛋白(hs-CRP)水平,同时对两组患者进行神经功能缺损评分(NIHSS)及简易精神状态量表评分(MMSE),评价治疗效果。结果:治疗组临床总有效率明显高于对照组、差异具有统计学意义(P<0.05);治疗后,两组患者的NIHSS评分均较治疗前明显降低(P<0.05),且治疗后治疗组NIHSS评分明显低于对照组(P<0.05);与治疗前相比,两组患者治疗后的MMSE评分均明显升高(P<0.05),且治疗组明显高于对照组(P<0.05);与治疗前相比,两组患者治疗后血清hs-CRP水平均较明显降低(P<0.05),且治疗后治疗组明显低于对照组(P<0.05);两组患者在治疗过程中均未发生明显不良反应。结论:养血清脑颗粒可降低急性脑梗死患者血清炎性因子同型半胱氨酸、超敏C反应蛋白水平,改善神经功能及认知功能。
Objective: To observe the impact of Yangxueqingnao granules on homocysteine( Hcy)and high sensitivity C-reactive protein( hs-CRP) in patients with acute cerebral infarction. Methods:100 cases with acute cerebral infarction were divided into the control group and the observation group.The control group received aspirin,atorvastatin calcium,neurotrophic and circulation-improved therapies,while the observation group were given Yangxueqingnao granules on the basis of the treatments for the control group. Before treatment and 4 weeks after treatment,serum Hcy and hs-CRP levels were detected,and NIHSS and MMSE scores were compared in the two groups. Result: The total effective rate of the observation group was significantly higher( P < 0. 05) than that of the control group. NIHSS scores and Hcy and hs-CRP levels of the observation group were significantly lower than those of the control group( P < 0. 05). MMSE scores in the observation group were significantly higher than in the control group( P < 0. 05). There were no obvious adverse reactions in both groups during the treatment. Conclusion: Yangxueqingnao granules can reduce the inflammatory factors( Hcy、hs-CRP) levels,improve the neurological function and cognitive function of patients with acute cerebral infarction.

关键词(KeyWords)： 中草药疗法;脑梗塞;同型半胱氨酸;超敏C反应蛋白;损伤严重度评分
Chinese herbal therapy;cerebral infarction;homocysteine;high sensitivity C-reactive protein;neurological function;injury severity score

Abstract:

Keywords:

基金项目(Foundation): 河北省中医药管理局科研计划项目(2014328)

作者(Author): 齐伟静,刘永刚,高爱民,马艳
QI Weijing,LIU Yonggang,GAO Aimin,MA Yan

DOI: 10.19367/j.cnki.1000-2707.2017.10.019

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