贵州医科大学学报

2015, v.40;No.175(04) 401-403

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灯盏花素联合前列地尔治疗脑梗死
Clinical Study on Effect of Breviscapine Combined with Alprostadil in the Treatment of Cerebral Infarction

周大淑;
ZHOU Dashu;Department of Neurology,First People's Hospital of Zigong City;

摘要(Abstract):

目的:探讨脑梗死患者采用灯盏花素联合前列地尔的治疗效果及其对神经功能缺损和血液流变学的影响。方法:100例脑梗死(CI)患者随机分成观察组和对照组,对照组给予灯盏花素注射液治疗,治疗组在对照组基础上加用前列地尔治疗,比较两组患者临床疗效及治疗前后的神经功能缺损评分(NIHSS)和血液流变学指标。结果:治疗后,观察组的总有效率为96.00%,显著高于对照组的72.00%,差异有统计学意义(P<0.05);两组患者治疗后的NIHSS评分均低于治疗前,以观察组更明显(P<0.05);两组治疗后,血液流变学指标水平均显著低于治疗前,以观察组更明显(P<0.05)。结论:在CI患者中采用灯盏花素联合前列地尔治疗,可有效提高临床疗效、减轻患者神经功能缺损程度、改善血流变,具有较高的应用价值。
Objective: To investigate the curative effect of breviscapine combined with alprostadil in patients with cerebral infarction as well as its effect on neurological deficit and hemorheology. Methods: One-hundred patients of cerebral infarction were randomly divided into observation group and control group,the control group were treated with breviscapine injection,the observation group was treated with breviscapine injection combined with alprostadil,the NIHSS score,blood rheology indexes before and after treatment and clinical effect of both groups were compared. Results: Total effective rate in the observation group was 96%,significantly higher than 72% of the control group,the differences was statistically significant( P < 0. 05); after treatment,NIHSS of both groups were significantly lower than pre-treatment,and decrease of observation group was more significant( P < 0. 05); the blood rheology index levels were significantly lower than pre-treatment,and decrease of observation group was more significant( P < 0. 05). Conclusions: Breviscapine combined with alprostadil therapy in patients with cerebral infarction can effectively improve the clinical curative effect,reduce the nerve function damage degree and improve blood rheology.

关键词(KeyWords): 灯盏花素;前列地尔;神经功能缺损;脑梗塞;血液流变学
breviscapine;alprostadil;nerve function impairment;cerebral infarction;blood rheology

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 周大淑;
ZHOU Dashu;Department of Neurology,First People's Hospital of Zigong City;

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DOI: 10.19367/j.cnki.1000-2707.2015.04.020

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