葛晓风,王鉴
GE Xiaofeng,WANG Jian

• 1:贵州医科大学儿科教研室
• 2:贵阳医学院
• 3:贵州医科大学附院儿科

摘要(Abstract)：

目的:探讨宫外发育迟缓(EUGR)早产儿的早期体格发育与胰岛素样生长因子(IGF-I)的关系。方法:早产儿60例,分为EUGR组及非EUGR组,以同期收治的足月并正常出生的新生儿30例为对照组,所有新生儿于出生后7 d与2周时测量体格发育指标(体重、头围、身长),同时采集外周血测定血清中IGF-I水平;随访3月后测量2组早产儿体格发育指标,记录体重、身长及头围发育落后例数和计算体格发育指标增长情况,同时测定血清IGF-I水平,分析体格发育指标增长与IGF-I水平相关性。结果:早产儿7d、14d时体重、头围、身长、IGF-I水平均低于对照组(P<0.05),EUGR组早产儿7d、14d时体重较非EUGR组低(P<0.05);随访3月发现EUGR组早产儿体重、头围、身长及IGF-I水平低于非EUGR组(P<0.05),体重、身长及头围发育落后例数高于非EUGR组(P<0.01、P<0.01、P<0.05),体重增长速度、头围及身长增长均低于非EUGR组(P<0.05);EUGR组和非EUGR组IGF-I水平与体重增长速度、头围及身长增长均呈正相关(r=0.399、0.453、0.377、0.615、0.443、0.435,P<0.05)。结论:IGF-I水平变化与早产儿体格发育相关,EUGR早产儿更明显。
Objective: To investigate the relationship between early-stage physical development of premature infants with extrauterine growth retardation and IGF-I level. Methods: Sixty premature infants were divided into extrauterine growth retardation group( EUGR group,31 cases) and non extrauterine growth retardation group( non-EUGR group,29 cases),meanwhile 30 full-term normal infants hospitalized during the same period were selected as control group. The physical development indexes( weight,head circumference,height) were measured 7 days and 14 days after birth. Meanwhile,the peripheral blood was collected and the IGF-I level of serum was determined. 3 months after birth,the physical development indexes of premature infants in 2 groups were measured again,the retardation cases were recorded in terms of weight,head circumference and height and the growth of physical development index were calculated. Meanwhile,the IGF-I level of serum was determined and the relevance between growth of physical development indexes and IGF-I level was analyzed. Results: The weight,head circumference,height and IGF-I level of premature group infants were lower than their counterparts of full-term infants on their 7thday,14 thday after birth.( P < 0. 05). The weight of EUGR group was lower than that of non-EUGR group on their 7thday,14 thday after birth( P < 0. 05). The weight,head circumference,height and IGF-I level of EUGR group were significantly lower than their counterparts of non-EUGR group on their 90thday( P < 0. 05). The growth rate of weight,head circumference and height of EUGR group were lower than those of non EUGR group. There was a positive correlation between IGF-I level and development speed of weight,head circumference,height( r = 0. 399,0. 453,0. 377,0. 615,0. 443,0. 435,P < 0. 05). Conclusion:IGF-I level is relevant to physical development of EUGR premature infants.

关键词(KeyWords)： 早产儿;宫外发育迟缓;早期体格发育;胰岛素样生长因子-I;发育
premature infant;extrauterine growth retardation;early physical development;insulin-like growth factor-I;development

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技厅科学技术基金[黔科合J字(2009)2160号]

作者(Author): 葛晓风,王鉴
GE Xiaofeng,WANG Jian

DOI: 10.19367/j.cnki.1000-2707.2015.07.020

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