肖霞,郭轶,王童,宗贝歌,陈振海,赵建梅
XIAO Xia,GUO Yi,WANG Tong,ZONG Beige,CHEN Zhenhai,ZHAO Jianmei

• 1:重庆大学附属中心医院重庆市急救医疗中心普通外科

摘要(Abstract)：

目的 探究基于患者主观评定量表（PG-SGA）的个性化营养干预方案对结直肠癌（CRC）患者术后的影响。方法 选取CRC手术患者150例随机均分为对照组和干预组，对照组给予常规营养指导干预，干预组给予PG-SGA个性化营养干预；比较两组患者干预前（术后第1天）和干预后（干预结束后第1天）营养状况[血红蛋白（Hb）、前白蛋白（PA）、转铁蛋白（TRF）]、免疫功能[免疫球蛋白G(IgG)、IgA、IgM]、炎症反应[核因子-κB(NF-κB)、白细胞介素-1(IL-1)、肿瘤坏死因子（TNF-α）、白细胞介素-8(IL-8)]、术后并发症及生活质量[生活质量综合评定问卷（GQOL-74）]。结果 干预后，干预组Hb、PA、TRF、IgG、IgA、IgM水平、GQOL-74量表评分高于对照组，差异有统计学意义（P<0.05）;NF-κB、IL-1、TNF-α、IL-8水平低于对照组，差异有统计学意义（P<0.05）；术后并发症总发生率低于对照组，差异有统计学意义（P<0.05）。结论 PG-SGA个性化营养干预可改善CRC手术患者的营养状况和免疫功能，减轻机体炎症反应，降低术后并发症发生，提高生活质量。
Objective To investigate the effect of personalized nutrition intervention based on Selfrating Subjective Rating Scale(PG-SGA) on postoperative prognosis of patients with colorectal cancer(CRC).Methods A total of 150 CRC patients were randomly divided into control group and intervention group. The control group was given routine nutrition interventions, and intervention group was given PG-SGA personalized nutrition intervention. Nutritional status [ Hemoglobin( Hb),prealbumin(PA), transferrin(TRF)], immune function [immunoglobulin G(IgG), IgA, IgM],inflammatory response [ nuclear factor-κB( NF-κB), interleukin-1( IL-1), tumor necrosis factor α(TNF-α), IL-8] complications and quality of life [ Questionnaire for Comprehensive Assessment of Quality of Life(GQOL-74)] of pre-intervention(1d after surgery) and post-intervention(1d after the intervention ended) were compared between both groups.Results After intervention, the levels of Hb, PA, TRF, IgG, IgA, IgM, and GQOL-74 scores in intervention group were significantly higher than those of control group, differences were statistically significant(P< 0. 05), while the levels of NF-κB, IL-1, TNF-α and IL-8 were significantly lower than those of control group(P< 0. 05). The total incidence of postoperative complications was significantly lower than that of control group,differences were statistically significant(P< 0. 05).Conclusion PG-SGA personalized nutrition intervention can improve the nutritional status and immune function of CRC patients, reduce the inflammatory response, reduce the incidence of postoperative complications, and improve quality of life.

关键词(KeyWords)： 自评主观评定量表;个性化营养干预;结直肠癌;炎症反应;预后
patient self-rating subjective rating scale;personalized nutrition intervention;colorectal cancer(CRC);inflammatory response;prognosis

Abstract:

Keywords:

基金项目(Foundation): 重庆市自然科学基金面上项目（cstc2020jcyj-msxmx0645）

作者(Author): 肖霞,郭轶,王童,宗贝歌,陈振海,赵建梅
XIAO Xia,GUO Yi,WANG Tong,ZONG Beige,CHEN Zhenhai,ZHAO Jianmei

DOI: 10.19367/j.cnki.2096-8388.2022.06.020

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