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甘草酸铵的抗炎作用
Anti-inflammatory Effects of Monoammonium Glycyrrhetate

黄能慧，李诚秀，罗俊，李玲，李建英
Huang Nenghui et al (Department of Pharmacology, Guiyamg Medical college)

1:贵阳医学院药理学教研室

摘要(Abstract)：

甘草酸铵注射给药，对巴豆油、醋酸所致的急性炎症、棉球所诱发的慢性炎症、Ｆｒｅｕｎｄ＇ｓ完全佐剂所致的免疫性炎症均具有抑制作用，能减轻急性炎症的红肿反应，以及抑制慢性炎症所致的肉芽组织增生。
Modern pharmacologists believe that glycyrrhiza uralensis fisch has an adrenocortin-like effect.Here we report the experimental results of anti-inflammatory effects of monoammonium glycyrrhetate (MG) in our laboratory. 1). The edema of ears of mice were induced by croton oil. The signi ficant inhibitory action was shown by the differences of ear-weights, The weights of ears were 15. 50±2.71mg in control group, 12. 47±1. 76 mg in the group of MG 100 mg/kg and 12. 31±1. 72 mg in the group of MG 300 mg/kg. 2). In experimental mice, MG had an obvious inhibitory effect on the increased capillary permeability induced acetic acid. The inhibitory effect was shown by the differences of permeable Evans' Blue which were 28. 12±10. 00μg/ml in control group, 20. 63±6. 88μg/ml in the groop of MG 100 mg/kg (P<0. 05) and 18. 75 μg/ml in the group of MG 300 mg/ks (P<0. 01) 3).There was an obvious inhibitory effect of MG on mouse-foot swell induced by Freund' s adjuvant. The differences of measured thickness of foot hell were 0. 41±0. 26 mm in control group, 0.23±0.11 mm in the group of MG 100 mg/kg and 0. 22±0.13 mm in the group of MG 300 mg/kg (P< 0. 05).4). MG might decrease the proliferation of granulation tissue of rats induced by cotton.The weights of the proliferation were 169.13±10.17 mg in MG group of 240 mg/kg and 200. 63±30. 80 mg in control group (P<0. 05). The results suggested that there is a significant inhibitory effect of MG on acute or chronic inflammation.

关键词(KeyWords)： 甘草酸铵，炎症，肉芽肿
monoammonium glycyrrhetate; inflammation; granuloma

基金项目(Foundation): 贵州省科委赞助

作者(Author): 黄能慧，李诚秀，罗俊，李玲，李建英
Huang Nenghui et al (Department of Pharmacology, Guiyamg Medical college)

DOI: 10.19367/j.cnki.1000-2707.1995.01.009

参考文献(References)：

1李诚秀。七见白马散的药理作用研究。贵阳医学院学报，1990，15（1）：402徐叔云，药理学实验方法学。北京：人民卫生出版社，1982．525页3陈奇。中药药理实验。贵阳：贵州人民出版社，1988．85页4张宝恒，甘草药理研究的进展，药学学报，1964，（3）：623

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227	2023/1/29	zFPWdwPk	testing@example.com	Mr. bcc:009247.289-8819.289.0af0d.19386.2@bxss.me	e
228	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
229	2023/1/29	zFPWdwPk bcc:009247.289-8821.289.0af0d.19386.2@bxs	testing@example.com	Mr.	e
230	2023/1/29	zFPWdwPk	testing@example.com	../../../../../../../../../../../../../../etc/passwd	e
231	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
232	2023/1/29	zFPWdwPk	testing@example.com	../../../../../../../../../../../../../../windows/win.ini	e
233	2023/1/29	zFPWdwPk	testing@example.com	file:///etc/passwd	e
234	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
235	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
236	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
237	2023/1/29	zFPWdwPk	testing@example.com	../Mr.	e
238	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
239	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
240	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
241	2023/1/29	../../../../../../../../../../../../../../etc/pass	testing@example.com	Mr.	e
242	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
243	2023/1/29	../../../../../../../../../../../../../../windows/	testing@example.com	Mr.	e
244	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
245	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
246	2023/1/29	zFPWdwPk	testing@example.com	Mr.
247	2023/1/29	file:///etc/passwd	testing@example.com	Mr.	e
248	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
249	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
250	2023/1/29	../zFPWdwPk	testing@example.com	Mr.	e
251	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
252	2023/1/29	zFPWdwPk		Mr.	e
253	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
254	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
255	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
256	2023/1/29	Z2tUMHVQdEo=	testing@example.com	Mr.	e
257	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
258	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
259	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
260	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
261	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
262	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
263	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
264	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
265	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
266	2023/1/29	zFPWdwPk	testing@example.com	Mr.	http://dicrpdbjmemujemfyopp.zzz/yrphmgdpgulaszriylqiipemefmacafkxycjaxjs?.jpg
267	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
268	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
269	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
270	2023/1/29	zFPWdwPk	testing@example.com	Mr.	Http://bxss.me/t/fit.txt
271	2023/1/29	zFPWdwPk	testing@example.com		e
272	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
273	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
274	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
275	2023/1/29	zFPWdwPk	testing@example.com	Mr.	http://bxss.me/t/fit.txt?.jpg
276	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
277	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
278	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
279	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
280	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
281	2023/1/29		testing@example.com	Mr.	e
282	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
283	2023/1/29	zFPWdwPk	testing@example.com	Mr.	/etc/shells
284	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
285	2023/1/29	zFPWdwPk	testing@example.com	Mr.	c:/windows/win.ini
286	2023/1/29	zFPWdwPk	testing@example.com	Mr.	bxss.me
287	2023/1/29	zFPWdwPk	http://dicrpdbjmemujemfyopp.zzz/yrphmgdpgulaszriylqiipemefmacafkxycjaxjs?.com	Mr.	e
288	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
289	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
290	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
291	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
292	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
293	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
294	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
295	2023/1/29	zFPWdwPk	Http://bxss.me/t/fit.txt	Mr.	e
296	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
297	2023/1/29	zFPWdwPk	http://bxss.me/t/fit.txt?.com	Mr.	e
298	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
299	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
300	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
301	2023/1/29	zFPWdwPk	/etc/shells	Mr.	e
302	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
303	2023/1/29	zFPWdwPk	c:/windows/win.ini	Mr.	e
304	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
305	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
306	2023/1/29	zFPWdwPk	bxss.me	Mr.	e
307	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
308	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
309	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
310	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
311	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
312	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
313	2023/1/29	zFPWdwPk	testing@example.com	http://dicrpdbjmemujemfyopp.zzz/yrphmgdpgulaszriylqiipemefmacafkxycjaxjs?.	e
314	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
315	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
316	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
317	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
318	2023/1/29	zFPWdwPk	testing@example.com	Http://bxss.me/t/fit.txt	e
319	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
320	2023/1/29	zFPWdwPk	testing@example.com	http://bxss.me/t/fit.txt?.	e
321	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
322	2023/1/29	zFPWdwPk	testing@example.com	/etc/shells	e
323	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
324	2023/1/29	zFPWdwPk	testing@example.com	c:/windows/win.ini	e
325	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
326	2023/1/29	zFPWdwPk	testing@example.com	Mr.	addPaperComment.ashx
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330	2023/1/29	zFPWdwPk	addPaperComment.ashx	Mr.	e
331	2023/1/29	zFPWdwPk	addPaperComment.ashx/.	Mr.	e
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333	2023/1/29	http://bxss.me/t/fit.txt?.jpg	testing@example.com	Mr.	e
334	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
335	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
336	2023/1/29	/etc/shells	testing@example.com	Mr.	e
337	2023/1/29	zFPWdwPk	testing@example.com	addPaperComment.ashx	e
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339	2023/1/29	bxss.me	testing@example.com	Mr.	e
340	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
341	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
342	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
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345	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
346	2023/1/29	addPaperComment.ashx	testing@example.com	Mr.	e
347	2023/1/29	addPaperComment.ashx/.	testing@example.com	Mr.	e
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366	2023/1/29	zFPWdwPk	testing@example.com	1	1
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477	2023/1/29	zFPWdwPk	testing@example.com	Mr.	e
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中国知网

贵州医科大学学报

1995, (01)

甘草酸铵的抗炎作用
Anti-inflammatory Effects of Monoammonium Glycyrrhetate

黄能慧，李诚秀，罗俊，李玲，李建英
Huang Nenghui et al (Department of Pharmacology, Guiyamg Medical college)

参考文献(References)：

文章评论(Comment)：

贵州医科大学学报

1995, (01)

甘草酸铵的抗炎作用Anti-inflammatory Effects of Monoammonium Glycyrrhetate

黄能慧，李诚秀，罗俊，李玲，李建英Huang Nenghui et al (Department of Pharmacology, Guiyamg Medical college)

参考文献(References)：

文章评论(Comment)：

甘草酸铵的抗炎作用
Anti-inflammatory Effects of Monoammonium Glycyrrhetate

黄能慧，李诚秀，罗俊，李玲，李建英
Huang Nenghui et al (Department of Pharmacology, Guiyamg Medical college)