贵州医科大学学报

1988, (04) 440-443

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古尼拟青霉对小白鼠的致畸试验
TERATOLOGICAL STUDY OF PAECILOMYCES GUNN(?)IN MICE

许庭良;姜俸蓉;罗明秀;
Xu Tingliang Department of Histology and Embryology

摘要(Abstract):

为确定古尼拟青霉有无胚胎毒和致畸作用,于母鼠妊娠的第6~14天每天灌胃给予0.6,2.0,6.0g/kg 古尼拟青霉。母鼠体重增长和胚胎外形、内脏及骨髓异常与阴性对照组(给予自来水)无明显差异。提示上述剂量范围内古尼拟青霉没有胚胎毒和致畸作用。给予五氯酚钠的阳性对照组则出现明显的胚胎毒和致畸作用。
A teratological study was made in mice.Paecilomyces gunnii was administered by gavage to pregnant mice at dose levels of 0.66,2.0,6.0g/kg/day on gestation days from six through fourteen.The gain in the maternal body weight and the anomalies in the embryon′s shape,viscera and skeleton revealed no statistically significant differences between the group treated by paecilomyces gudii and the control group treated by tap water.In conclusion,paecilo myces gunnii showd no embryotoxie and teratogenie effects in mice at dose levels up to 60g/kg/day. The significant embryotoxic and teratogenic effects were revealed in the positive control group treated by pentachlorophenol sodium salt.

关键词(KeyWords): 古尼拟青霉;胚胎;中毒;致畸胎物;动物实验;鼠
paecilomyces gunnii;embroy;poisoning;teratogens;animals,laboratory;rats

Abstract:

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作者(Author): 许庭良;姜俸蓉;罗明秀;
Xu Tingliang Department of Histology and Embryology

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DOI: 10.19367/j.cnki.1000-2707.1988.04.004

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