贵州医科大学学报

2010, v.35;No.143(02) 137-139+150

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菊黄上清含片中冰片β-环糊精包合物的制备工艺
Study on Preparation Technology of Borneol-β-cyclodextrin Inclusion Complex in Juhuang Shangqing Buccal Tablet

罗媛;郑林;兰燕宇;王永林;王爱民;李勇军;何迅;
LUO Yuan1,ZHENG Lin2,LAN Yanyu2,WANG Yonglin2,WANG Aimin2,LI Yongjun2,HE Xun2(1.Department of Pharmacy,Guizhou Provincial Hospital of Orthopedics,Guiyang 550004,Guizhou,China;2.School of pharmacology,Guiyang Medical College,Guiyang 550004,Guizhou,China)

摘要(Abstract):

目的:研究菊黄上清含片中冰片β-环糊精包合的最佳制备工艺。方法:采用正交试验设计,以冰片包合率、包合物收得率为考察指标,筛选较为合理的包合工艺;采用薄层色谱法、热重分析和差示热分析法对包合物进行了理化鉴别。结果:冰片和β-环糊精最佳包合比例为1∶6,包合温度40℃,搅拌时间2 h,确证冰片被β-环糊精成功包合。结论:优选的包合工艺简便、合理、可行,适用于工业生产。
Objective:To study the optimal preparation technology of borneol-β-cyclodextrin inclusion complex in Juhuang Shangqing buccal tablet.Methods: Orthogonal experiments were carried out,using oil-bearing ratio and inclusion ratio as evaluation indexes,to screen suitable clathration technique.The inclusion complex was identified by using methods of thin layer chromatography(TLC),thermogravimetric analysis(TGA) and differential thermal analyses(DTA).Results: The optimal preparation conditions for inclusion was as follows:the ratio of borneol and β-cyclodextrin as 1: 6,and stirring oil at 40℃ for 2 hours.Conclusions: The preparation technique is simple,reasonable,feasible,and is suitable for industrial production.

关键词(KeyWords): 菊黄上清含片;冰片;环糊精类;工艺学,制药
Juhuang Shangqing buccal tablet;borneolum syntheticum;cyclodextrins;technology,pharmaceutical

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技厅科研课题[黔科合计Z字(2009)4001];; 贵阳市科学技术计划项目[(2009)筑科中合同字第9-3-04号]

作者(Author): 罗媛;郑林;兰燕宇;王永林;王爱民;李勇军;何迅;
LUO Yuan1,ZHENG Lin2,LAN Yanyu2,WANG Yonglin2,WANG Aimin2,LI Yongjun2,HE Xun2(1.Department of Pharmacy,Guizhou Provincial Hospital of Orthopedics,Guiyang 550004,Guizhou,China;2.School of pharmacology,Guiyang Medical College,Guiyang 550004,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2010.02.009

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