贵州医科大学学报

2020, v.45;No.235(04) 477-481

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莫西沙星对老年CAP患者肺功能及血清CRP、PCT、sTREM-1水平的影响
Effects of Moxifloxacin on Pulmonary Function and Levels of Serum CRP,PCT and s TREM-1 in Elderly CAP Patients

陈晓红;陈秀红;陈向红;
CHEN Xiaohong;CHEN Xiuhong;CHEN Xianghong;Cadre Sanatorium of Hainan Province & Geriatric Hospital of Hainan Province;The Second Affiliated Hospital of Hainan Medical University;

摘要(Abstract):

目的:探讨莫西沙星对老年社区获得性肺炎(CAP)患者肺功能及血清C反应蛋白(CRP)、降钙素原(PCT)、可溶性髓系细胞表达触发受体1(s TREM-1)水平的影响。方法:83例老年CAP患者随机分为观察组(n=42)和对照组(n=41),对照组采用左氧氟沙星治疗,观察组患者采用莫西沙星治疗,均序贯治疗14 d;比较2组患者治疗14 d时的治疗效果及治疗过程中肝肾功能异常、恶心、腹泻及皮疹等不良反应的发生率;比较2组患者治疗前及治疗第14天时的用力肺活量(FVC)、第一秒用力呼气容积(FEV1)、第一秒用力呼气量占用力肺活量比值(FEV1/FVC)、呼气峰值流速(PEF)、用力呼气中期流速(MMEF_(75/25))、75%肺活量时的最大呼气流速(MEF_(75))、50%肺活量时的最大呼气流速(MEF_(50))、25%肺活量时的最大呼气流速(MEF_(25))及血清CRP、PCT、s TREM-1水平。结果:观察组患者治疗14 d时的治疗效果明显高于对照组,差异具有统计学意义(P <0. 05); 2组患者治疗过程中的不良反应发生率比较,差异无统计学意义(P>0. 05); 2组患者治疗14 d时的FVC、FEV1、FEV1/FVC、PEF、MMEF_(75/25)、MEF_(75)、MEF_(50)及MEF_(25)较治疗前明显升高,血清CRP、PCT、s TREM-1水平较治疗前明显降低,观察组较对照组变化更显著,差异有统计学意义(P <0. 05)。结论:莫西沙星对老年CAP患者序贯治疗效果优于左氧氟沙星,能有效改善患者的肺部通气及弥散功能,还能降低血清CRP、PCT及s TREM-1水平。
Objective: To investigate the effects of moxifloxacin on pulmonary function and serum C reactive protein( CRP),procalcitonin( PCT) and the levels of soluble myeloid cell expression trigger receptor 1( s TREM-1) in elderly patients with community-acquired pneumonia( LSP). Methods: The83 elderly CAP patients were randomly divided into observation group( n = 42) and control group( n= 41). The control group was treated with levofloxacin, observation group was treated with moxifloxacin,and all patients were treated with sequential therapy for 14 d. The therapeutic effect of14 d and the incidence of adverse reactions were compared such as abnormal liver and kidney function,nausea,diarrhea and rash during the treatment of 2 groups. The forced vital capacity( FVC),forced expiratory volume( FEV1),forced expiratory volume ratio( FEV1/FVC),peak expiratory flow rate( PEF),forced midexpiratory flow rate( MMEF_(75/25)),maximum expiratory flow rate( MEF_(75)) at75% vital capacity,maximum expiratory flow rate( MEF_(50)) at 50% vital capacity,maximum expiratory flow rate( MEF_(25)) at 25% vital capacity and the levels of serum CRP,PCT,s TREM-1 were compared in two groups. Results: At 14 d in the observation group,the therapeutic effect was significantly higher than that in the control group,and the difference was statistically significant( P <0. 05). There was no significant difference in the incidence of adverse reactions between the two groups( P > 0. 05). The FVC,FEV1,FEV1/FVC,PEF,MMEF_(75/25),MEF_(75),MEF_(50) and MEF_(25) of14 d in the two groups were significantly higher than before treatment,the levels of serum CRP,PCT and s TREM-1 was significantly lower than before treatment, and the difference was statistically significant in the observation group compared with the control group( P < 0. 05). Conclusion: The effect of moxifloxacin on sequential treatment of elderly CAP patients is better than levofloxacin,which can effectively improve pulmonary ventilation and diffusion function and reduce the levels of serum CRP,PCT and s TREM-1.

关键词(KeyWords): 肺炎,老年;C反应蛋白质;降钙素原;可溶性髓系细胞表达触发受体1;莫西沙星序贯治疗
pneumonia,old age;c-reactive protein(CRP);procalcitonin;soluble myeloid cell expression trigger receptor 1(s TREM-1);moxifloxacin sequential therapy

Abstract:

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基金项目(Foundation): 海南省自然科学基金(817373)

作者(Author): 陈晓红;陈秀红;陈向红;
CHEN Xiaohong;CHEN Xiuhong;CHEN Xianghong;Cadre Sanatorium of Hainan Province & Geriatric Hospital of Hainan Province;The Second Affiliated Hospital of Hainan Medical University;

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DOI: 10.19367/j.cnki.1000-2707.2020.04.019

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