贵州医科大学学报

2019, v.44;No.220(01) 68-71+75

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胸水腺苷脱氨酶、胸水和血清中γ-干扰素比值联合检测对结核性胸腔积液的诊断价值
Diagnostic Value of Combined Detection of Pleural Fluid Adenosine Deaminase and the Ratio of Pleural Fluid IFN-γ to Serum IFN-γ on Tuberculous Pleural Effusion

万方,罗浩,杨雪,唐静,杜娟,程义局
WAN Fang,LUO Hao,YANG Xue,TANG Jing,DU Juan,CHENG Yiju

摘要(Abstract):

目的:探讨胸水腺苷脱氨酶(ADA)水平、胸水和血清中的γ-干扰素(IFN-γ)比值单独或联合检测时对结核性胸腔积液的诊断价值。方法:84例胸腔积液患者,确诊结核性胸腔积液患者42例、恶性胸腔积液患者42例;采用ELISA法测定两组患者胸水及血清IFN-γ水平,并计算胸水IFN-γ与血清IFN-γ比值,同时收集患者胸水ADA检测结果,比较胸水ADA、胸水IFN-γ与血清IFN-γ比值单独及联合检测诊断结核性胸腔积液的特异度、敏感度。结果:结核性胸腔积液组患者的胸水ADA、胸水IFN-γ、血清IFN-γ及胸水IFN-γ与血清IFN-γ比值均高于恶性胸腔积液组(P<0.01),胸水ADA或胸水IFN-γ与血清IFN-γ比值单独检测时对结核性胸腔积液的诊断有较高的特异度及较低的敏感度,两者联合检测时对结核性胸腔积液诊断的敏感度和特异度均有所提高。结论:胸水ADA水平、胸水IFN-γ与血清IFN-γ比值联合检测对结核性胸腔积液有较高的诊断价值。
Objective:To investigate independent or combined diagnostic value on of hydrothoracic ADA,the ratio of pleural fuid IFN-γ to serum IFN-γ in the tuberculous pleural effusion.Methods:84 patients with pleural effusion,42 cases diagnosed as tuberculous pleural effusion and 42 cases of malignant pleural effusion.An enzyme linked immunosorption assay(ELISA) was used to determine the levels of IFN-γ in pleural effusion and serum IFN-γ in both groups of patients,which then calculated the ratio of hydrothoracic IFN-γ and serum IFN-γ.The results of ADA detection in pleural effusion were obtained by collecting the medical records of inpatients.When hydrothoracic ADA and the ratio of pleural fuid IFN-γ to serum IFN-γ were used independently and combined,the specificity and sensitivity were diagnosed for tuberculous pleural effusion.Results:The level of hydrothoracic ADA,and the ratio of pleural fuid IFN-γ to serum IFN-γ in the tuberculous pleural effusion group were significantly higher than those in malignant pleural effusion group(P<0.01).Hydrothoracic ADA,and the ratio of pleural effusion IFN-γ to serum IFN-γ independent diagnosis showed relatively higher specificity but relatively lower sensitivity;while the combined method showed improved specificity and sensitivity.Conclusion:The levels of the hydrothoracic ADA,the ratio of hydrothoracic IFN-γ to serum IFN-γ in tuberculous pleural effusion can improve the diagnostic value of tuberculous pleural effusion.

关键词(KeyWords): 胸腔积液;结核;腺苷脱氨酶;γ-干扰素;诊断
pleural effusion;tuberculosis;adenosine deaminase;interferon-gama;diagnosis

Abstract:

Keywords:

基金项目(Foundation): 2017年重大公共卫生专项基金资助项目[黔财社(2017)20号]

作者(Author): 万方,罗浩,杨雪,唐静,杜娟,程义局
WAN Fang,LUO Hao,YANG Xue,TANG Jing,DU Juan,CHENG Yiju

DOI: 10.19367/j.cnki.1000-2707.2019.01.013

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