陈永红,王素平
CHEN Yonghong,WANG Suping(Department of Public Health

• 1:广东医学院附属西乡人民医院社康科

摘要(Abstract)：

目的:研究药物流产后患者体内雌激素(E2)、孕激素(P)及人绒毛促性腺激素(hCG)水平与异常子宫出血的关系。方法:59例患者口服米非司酮配伍米索前列醇药物终止早期妊娠,将子宫出血时间超过14 d的30例患者作为异常子宫出血组,子宫出血时间少于14 d的29例患者作为对照组,比较2组外周静脉血清中E2、P及hCG水平。结果:两组患者体内E2差异无显著性(P>0.05),在出血第14天时,异常子宫出血组患者体内P明显高于对照组(P<0.05),在第14、18和22天hCG均高于对照组(P<0.05)。结论:药物流产后异常子宫出血与患者体内P和hCG水平有关。
Objective: To investigate the relationship of estrogen(E2),progesterone(P),and human chorionic gonadotrophin(hCG) levels with abnormal uterine bleeding in patients with drug abortion.Methods: A total of 59 patients taking mifepristone plus misoprostol for abortion were divided into two groups.In the control group(29 cases,group C),the time of uterine bleeding was less than 14 days;in the abnormal uterine bleeding(30 cases,group A),the time of uterine bleeding was more than 14 days.The levels of E2,P and hCG of the 2 groups in 14,18 and 22 days after initiation of bleeding were compared.Results: There was no significant difference of E2 levels between the 2 groups(P>0.05);On the 14th day,P level of group A was higher than that of group C(P<0.05);On the 14th,18th,and 22nd days,the hCG levels in group A were significantly higher than those in group C(P<0.05).Conclusion: The abnormal uterine bleeding in patients with medical abortion is related with P and hCG levels.

关键词(KeyWords)： 流产;子宫出血;雌激素类;孕激素类;绒毛膜促性性腺激素
abortion;uterine hemorrhage;estrogens;progestational hormone;chorionic gonadotropin

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 陈永红,王素平
CHEN Yonghong,WANG Suping(Department of Public Health

DOI: 10.19367/j.cnki.1000-2707.2013.02.010

参考文献(References)：

• [1]吕琼莹,张蔚,程静,等.手术流产与药物流产的临床结果比较的Meta分析[J].中华临床医师杂志,2012(14):3996-4001.
• [2]Bouchard P,Chabbert-Buffet N,Fauser BC.Selectiveprogesterone receptor modulators in reproductive medi-cine:pharmacology,clinical efficacy and safety[J].Fer-til Steril,2011(5):1175-1189.
• [3]Spitz IM.Mifepristone:where do we come from andwhere are we going?Clinical development over a quarterof a century[J].Contraception,2010(5):442-452.
• [4]傅晓敏,王雯,黄丽丽.药物流产后异常子宫出血者子宫内膜中血管生成素1、2的表达[J].解剖学报,2007(6):751-754.
• [5]Pregnancy termination with mifepristone and gemeprost:amulticenter comparison between repeated doses and a sin-gle dose of mifepristone.World Health Organization[J].Fertil Steril,1991(1):32-40.
• [6]程雪梅.米非司酮对子宫肌瘤雌、孕激素水平及受体表达的影响[J].贵阳医学院学报,2012(4):419-420.
• [7]吴小容.大剂量米非司酮对绝经后子宫内膜息肉的雌、孕激素受体及Ki-67、Bcl-2的影响[J].中国医药导报,2008(5):40-41.
• [8]郭春明,孙刚.哺乳类动物妊娠晚期孕激素撤退的三种机制[J].生理学报,2010(2):171-178.
• [9]Rorbye C,Norgaard M,Nilas L,et al.Prediction of latefailure after medical abortion from serial beta-hCG meas-urements and ultrasonography[J].Hum Reprod,2004(1):85-89.
• [10]刘庆.药流后阴道出血宫腔刮出物的病理观察[J].中国妇幼保健,2013(3):575-576.

文章评论(Comment)：