贵州医科大学学报

2017, v.42;No.205(10) 1172-1175

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阿托伐他汀钙联合曲美他嗪对心力衰竭患者CRP、IL-6、RDW及BNP水平的影响
Effect of Atorvastatin Calcium Tablets Combined with Trimetazidine on CRP,IL-6,RDW and BNP Level Changes of Heart Failure Patients

李若淳,钟璟,林明春,苏艳丽,吴昌学
LI Ruochun,ZHONG Jing,LIN Mingchun,SU Yanli,WU Changxue

摘要(Abstract):

目的:探讨阿托伐他汀钙联合曲美他嗪对心力衰竭患者C反应蛋白(CRP)、白介素6(IL-6)、红细胞分布宽度(RDW)及脑尿钠肽(BNP)水平的影响。方法:75例心力衰竭患者作为观察组(按照NYHA心功能分级分为I级~IV级),45例健康体检者为对照组,观察组患者给予阿托伐他汀钙联合曲美他嗪治疗4周;对照组于体检时、观察组患者于治疗前和治疗结束时,采集空腹静脉血,分别测定抗凝全血的RDW、血浆的CRP、IL-6及BNP含量;比较对照组和不同NYHA心功能分级(I级-IV级)的观察组患者治疗前后的CRP、IL-6、RDW及BNP水平。结果:观察组患者治疗前的RDW、BNP、CRP及IL-6水平高于对照组(P<0.05),随着心力衰竭患者心功能从I级到IV级,患者RDW、BNP、CRP及IL-6含量逐渐升高,不同等级心功能的测定结果比较,差异有统计学意义(P<0.05);治疗后,心力衰竭患者各项指标均较治疗前降低,其中RDW、BNP降低程度更为明显,差异有统计学意义(P<0.05)。结论:阿托伐他汀钙联合曲美他嗪治疗心力衰竭患者后,患者心脏功能有所改善,主要影响RDW、BNP。
Objective: To analyze the effect of Atorvastatin Calcium tablets combined with Trimetazidine on CRP,IL-6,RDW and BNP level changes of heart failure patients. Methods: 75 patients with heart failure as the observation group( Level I to Level IV was divided according to NYHA cardiofunction classification). At the same time,45 healthy persons were selected as control group. Observation group received Atorvastatin Calcium tablets combined with Trimetazidine treatment for 4 weeks;extract venous blood of the control group,observation group before and after treatment; the results of RDW,serum CRP,IL-6 and BNP content were measured; RDW,serum CRP,IL-6 and BNP levels of observation group before and after treatment with various NYHA cardio-function classification were compared with control group. Results: The RDW,BNP,CRP and IL-6 level of observation group before treatment were higher than that of the control group( P < 0. 05); the higher the cardiac function of the patients from Level I to Level IV,the higher the concentration index. Comparison of various cardiofunction showed significant differences( P < 0. 05); after treatment,the concentration of RDW and BNP decreased obviously,and the difference was significant( P < 0. 05). Conclusion: Atorvastatin Calcium tablets combined with Trimetazidine treatment on patients with heart failure showed improved cardiac function,which majorly influence RDW and BNP.

关键词(KeyWords): 心力衰竭;C反应蛋白;白介素6;红细胞分布宽度;脑尿钠肽
heart Failure;C reactive protein;interleukin 6;red cell distribution width;brain natriuretic peptide

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技厅科技计划课题[黔科合LH字(2015)7330];贵州省科技厅计划项课题[黔科合LG字(2012)009]

作者(Author): 李若淳,钟璟,林明春,苏艳丽,吴昌学
LI Ruochun,ZHONG Jing,LIN Mingchun,SU Yanli,WU Changxue

DOI: 10.19367/j.cnki.1000-2707.2017.10.013

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