贵州医科大学学报

2007, No.127(04) 382-384+387

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宫颈癌p53和c-erbB-2蛋白表达及临床意义
The Expression of p53 and c-erbB-2 in Cervical Carcinoma and Its Significance in Prognosis of the Disease

周华宁;任崇敏;冉立;孙渝;
ZHOU Huaning1,REN Congmin1,RAN Li1,SUN Yu2(1.Department of Oncology,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China;2.Department of Pathology,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China)

摘要(Abstract):

目的:探讨宫颈癌p53、c-erbB-2蛋白的表达及临床意义。方法:采用免疫组织化学E liV ision二步法检测43例宫颈癌组织切片的p53、c-erbB-2蛋白表达,并结合临床病理资料进行分析。结果:(1)p53、c-erbB-2蛋白阳性表达率分别为74.4%和69.8%;(2)p53蛋白的表达在鳞癌高于腺癌(P<0.05),其表达与年龄、临床分期、临床分型、病理分级、宫旁浸润、近期疗效无明显相关(P>0.05);(3)c-erbB-2蛋白的表达在鳞癌的病理分级、宫旁浸润中有显著差异(P<0.01),在临床分期的表达中也有显著差异(P<0.05),但与年龄、临床分型、近期疗效、病理类型、腺癌的病理分级无明显相关(P>0.05);(4)p53与c-erbB-2蛋白共同阳性表达在癌旁浸润中,有显著差异(P<0.01),二者阳性表达随宫颈癌临床分期表达增高(P<0.05)。结论:c-erbB-2蛋白阳性表达与宫颈癌恶性程度呈正相关;p53与c-erbB-2蛋白共同阳性表达与癌旁浸润有关,随临床分期表达增高,提示宫颈癌的发生发展可能有多种癌基因共同参与。
Objective: To investigate the expression of p53 and c-erbB-2 in cervical carcinoma and its significance in the prognosis of the disease.Methods: The p53 and c-erbB-2 expressed proteins in tissular slices of 43 cases of cervical carcinoma was detected with immunohistochemical EliVision technique.The data were analyzed referring with the disease progress and curative results of the patients.Results:(1) The positive expression rates of p53 and c-erbB-2 were 74.4% and 69.8% respectively;(2) Positive expression of p53 was higher in squamous carcinoma than in adenocarcinoma(P<0.05),but it was not obviously related to age,clinical staging,clinical types,degree of tissue differentiation,or short term curative results(P>0.05);(3) Positive expression of c-erbB-2 was obviously correlated with the disease clinical staging(P<0.05).It was also obviously correlated with degree of tissue differentiation in squamous carcinoma,(ⅡVSⅠ,P<0.01;ⅢVSⅠ,P<0.01) and infiltration of cervical(P<0.01),but it was not obviously related to age,clinical types,clinical response to radiotherapy or operation,pathological types,or degree of tissue differentiation in adenocarcinoma;(4) Co-expression of p53 and c-erbB-2 was obviously correlated with cervical infiltration(P<0.01),and increased along with the clinical staging of cervical carcinoma(P<0.05).Conclusions: In cervical carcinoma,the expression of c-erbB-2 protein positively correlated with the malignancy.Co-expression of p53 and c-erbB-2 is obviously correlated with the progress of the disease and the infiltration surrounding the cancer,which suggest that there might be multiple genes involved in the development of cervical carcinoma.

关键词(KeyWords): 癌,鳞状细胞;癌,腺泡细胞;子宫颈;蛋白质p53;基因,erbB-2
carcinoma,squamous cell;carcinoma,acinar cell;cervix uteri;protein p53;gene,erbB-2

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作者(Author): 周华宁;任崇敏;冉立;孙渝;
ZHOU Huaning1,REN Congmin1,RAN Li1,SUN Yu2(1.Department of Oncology,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China;2.Department of Pathology,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China)

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DOI: 10.19367/j.cnki.1000-2707.2007.04.016

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