贵州医科大学学报

2007, No.129(06) 583-585

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贵州省苗族、水族人群线粒体DNA RegionⅤ遗传多态分析
An Analysis on the Polymorphism in Region Ⅴ of Mitochondrial DNA in Miao and Shui People in Guizhou Province

何燕,张婷,单可人,王婵娟,官志忠,任锡麟
HE Yan,ZHANG Ting,SHAN Keren,WANG Chanjuan,GUAN Zhizhong,REN Xilin(The Key Laboratory of Molecular Biology

摘要(Abstract):

目的:分析世居贵州省雷山县苗族、三都县水族人群线粒体DNA(mtDNA)RegionⅤ的遗传多态性。方法:采用聚合酶链反应-聚丙烯酰胺凝胶电泳(PCR-PAGE)法对91份苗族和96份水族样本的线粒体DNARegionⅤ区进行多态分析。结果:两个群体中均只发现标准型和短型(9bp缺失)两种多态,9bp缺失基因频率分别为:雷山苗族25.27%、三都水族25.00%。结论:上述两个少数民族群体中线粒体DNA RegionⅤ区短型多态基因频率较高,与其地域分布相一致。
Objective:To analyze the polymorphism in region Ⅴof mitochondrial DNA(mt DNA)in Miao people and Shui people in Guizhou.Methods:Polymerase chain reaction and polyacrylamide gel electrophoresis(PCR-PAGE)were used in the study.Results:Only two kinds of polymorphism were found in these populations.One belonged to standard pattern,and the other was short pattern(namely 9 bp deletion).The frequencies of short pattern in Miao and Shui people were 25.27%(23/91)and 25.00%(24/96)respectively.Conclusion:The frequencies of short pattern are relatively high in Miao and Shui people in Guizhou,which is in consistent with their regional distribution in other areas.

关键词(KeyWords): DNA,线粒体;多态现象(遗传学);苗族;水族
DNA,mitochondrial;polymorphism(genetics);Miao people;Shui people;

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技厅基金项目[黔科合(2004)3007号]

作者(Author): 何燕,张婷,单可人,王婵娟,官志忠,任锡麟
HE Yan,ZHANG Ting,SHAN Keren,WANG Chanjuan,GUAN Zhizhong,REN Xilin(The Key Laboratory of Molecular Biology

DOI: 10.19367/j.cnki.1000-2707.2007.06.008

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