胡贵贤,金红君
HU Guixian,JIN Hongjun

• 1:贵阳护理职业学院门诊部
• 2:重庆医科大学检验医学院

摘要(Abstract)：

目的:探讨血清胱抑素C(Cys C)联合β2微球蛋白(β2-MG)检测在糖尿病肾病(DN)早期诊断中的价值。方法:以尿微量白蛋白/尿肌酐比值(MAlb/Cr)为依据将73例糖尿病患者分为单纯糖尿病组、DN早期组及DN组,设健康对照组;比较各组血清Cys C、β2-MG、尿素(Urea)及肌酐(Scr)的变化及在各组中阳性率,分析血清Cys C、β2-MG、尿MAlb/Cr三者间的相关性。结果:DN早期组Cys C、β2-MG含量较单纯糖尿病组升高,差异有统计学意义(P﹤0.05,P﹤0.01);阳性率仅在DN早期组血清Cys C、β2-MG明显高于Urea、Scr阳性率,差异有统计学意义(P﹤0.05);血清Cys C与β2-MG、MAlb/Cr间呈正相关(r=0.951、0.804,P<0.05),β2-MG与MAlb/Cr间仍呈正相关(r=0.741,P﹤0.05)。结论:联合检测血清Cys C和β2-MG对DN有较好的早期诊断价值。
Objective: To investigate the clinical value of serum Cystatin C combined with β2-MG in early diagnosis of Diabetic Nephropathy. Methods: Based on MAlb / Cr,73 diabetic patients were divided into: diabetes without nephropathy group,early diabetic nephropathy group,diabetic nephropathy group and control group. Comparing changes and positive rate in the serum Cys C,β2-MG,Urea,CR of each group,analyzing correlation among serum Cys C,β2-MG and MAlb / Cr. Results:Cys C and β2-MG in early diabetic nephropathy group were higher than diabetic nephropathy group,differences were statistically significance( P ﹤ 0. 05,P < 0. 01); Serum Cys C and β2-MG positive rates were significantly higher than Urea and Scr positive rates in early diabetic nephropathy group( P< 0. 05); Serum Cys C,β2-MG and MAlb / Cr was positively correlated( r = 0. 951,0. 804,P < 0.05),β2-MG and MAlb / Cr was positively correlated( r = 0. 741,P ﹤ 0. 05). Conclusion: Serum Cys C combined with β2-MG can serve as effective way for early diabetic nephropathy diagnosis.

关键词(KeyWords)： 血清胱抑素C;β2微球蛋白;糖尿病;糖尿病肾病
serum cystatin C;β2-microgloblin;diabetes;diabetic nephropathy

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 胡贵贤,金红君
HU Guixian,JIN Hongjun

DOI: 10.19367/j.cnki.1000-2707.2015.07.016

参考文献(References)：

• [1]张路霞,王海燕.从流行病学的角度探讨我国糖尿病肾病的发病趋势及对策[J].中华内科杂志,2010(9):804-805.
• [2]常宝成.糖尿病肾病患者如何合理选择降糖药物[J].糖尿病新世界,2009(8):26-27.
• [3]Fu MH,Chen J,Chen Q.Research Progress of Cystatin C and Diabetic Nephropathy[J].Chinese General Practice,2013(1):229-231.
• [4]孙曙华.糖尿病患者定期检测尿微量白蛋白与尿肌酐比的临床意义[J].实验与检验医学,2010(1):87-89.
• [5]朱亮,奚耀,钱明义.血清光抑素C和尿N-乙酰-β-D-氨基葡萄糖苷酶对脓毒症早期肾功能损伤的预测价值[J].中国临床医学,2011(4):465-466.
• [6]王艳春,井丽君,杨立雅,等.金标法快速检测血清β2-MG在糖尿病和高血压早期肾功能损伤中的应用[J].重庆医学,2015(12):1688-1690.
• [7]陆胜,季雄娟.血清光抑素C联合尿微量白蛋白质检测在妊娠期,高血压疾病早期肾损害诊断中的价值[J].实用临床医学杂志,2014,(16):188-190.
• [8]冯绍明,龚英峰,裴荣光.血清光抑素C与早期高血压肾损害的相关性研究[J].实用临床医药杂志,2013(13):121-123.
• [9]徐菲,包进,赵昕亚.胱抑素C的临床应用研究进展[J].检验与临床,2012(12):1482-1483.
• [10]Jeon YK,Kim MR,Huh JE.Cystatin C as an early biomarker of nephropathy in patients with type 2 diabetes[J].Korean Med Sci,2011(2):258-263.
• [11]Xu FQ,Yang YQ,Liu J.Research Progress in Detection of Serum Cystatin C and Its Clinical Application[J].Medical Recapitulate,2013(16):2907.

文章评论(Comment)：