贵州医科大学学报

2015, v.40;No.178(07) 750-753

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妊娠期糖尿病伴慢性牙周炎患者血清TNF-α及IL-10水平
The Change of Serum TNF-α and IL-10 Levels in Gestational Diabetes Mellitus Patients with Chronic Periodontisis

马小红;
MA Xiaohong;Chengdu Central Hospital for Women and Children;

摘要(Abstract):

目的:探讨妊娠期糖尿病(GDM)伴慢性牙周炎(CP)患者血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)水平变化及相关性。方法:妊娠26~36周的单胎孕妇80例,根据病例资料分为(GDM+CP)组、GDM组、CP组、及健康孕妇(H组),每组20例,检测4组患者牙周临床指标菌斑指数(PI)、牙周探诊深度(PD)、临床附着水平丧失(CAL)和探针出血(BOP)阳性位点率,检测空腹、服糖后1 h和2 h 75%糖耐量试验的血糖值;并采用放射免疫法检测患者血清中TNF-α、IL-10的水平,并与牙周参数进行相关性分析。结果:(GDM+CP)组1h、2h血糖值均比GDM组升高(P<0.05),(GDM+CP)组、GDM组、CP组及H组牙周临床指标(PD、CAL、BOP)和血清TNF-α水平均呈下降趋势,差异有统计学意义(P<0.05);而血清IL-10水平呈上升趋势,差异有统计学意义(P﹤0.05);TNF-α与PD、CAL和1 h血糖值、2 h血糖值之间呈正相关(r=0.377、0.673、0.273、0.338);IL-10与PD、CAL、1 h血糖值、2 h血糖值之间呈负相关(r=-0.389、-0.579、-0.270、-0.322)。结论:GDM伴CP患者牙损害较单纯CP患者重,GDM伴CP的病理机制可能与TNF-α、IL-10相关。
Objective: To investigate the changes of tumor necrosis factor-alpha( TNF-α) and interleukin-10( IL-10) levels in gestational diabetes mellitus( GDM) patients with chronic periodontisis( CP),and to explore the possible relationship of TNF-α and IL-10 with periodontal indexes.Methods: Eighty single pregnant women( 26 ~ 36 weeks of pregnancy) were selected,among them,20 were GDM patients with CP( group GDM + CP),20 patients with CP( group CP),20 patients with GDM( group GDM),20 healthy patients( group H). The periodontal indexes such as plaque index( PI),periodontal probing depth( PD),clinical attachment loss( CAL) and probe bleeding( BOP)positive rate were recorded and the results of oral glucose tolerance test( OGTT) were analyzed. The serum levels of TNF-α and IL-10 were detected by radioimmunoassay,and the correlation between serum TNF-α,IL-10 levels and periodontal indexes was analyzed. Results: In group GDM + CP,1h blood glucose( 1h PG),2h blood glucose( 2h PG) were higher than those of group GDM( P < 0. 05),periodontal indexes and the serum TNF-α levels of group GDM + CP,group GDM,group CP and group H exhibited gradually declining trend,serum IL-10 levels showed gradually rising trend,the differences between each other were statistically significant( P ﹤ 0. 05). TNF-α was positively correlated with PD,CAL,1h PG,2h PG( r = 0. 377,0. 673,0. 273 and 0. 338),respectively. IL-10 were negatively correlated with PD,CAL,1h PG,2h PG( r =-0. 389,-0. 579,-0. 270 and-0.322). Conclusions: The tooth damage in patients with GDM and CP are more complicated than that of CP patients,TNF-α and IL-10 may play a role in the development of GDM and CP.

关键词(KeyWords): 牙周炎;糖尿病,妊娠;牙菌斑指数;肿瘤坏死因子-α;白细胞介素-10
periodontisis;diabetes,gestational;dental plaque index;tumor necrosis factor-alpha;interleukin-10

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作者(Author): 马小红;
MA Xiaohong;Chengdu Central Hospital for Women and Children;

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DOI: 10.19367/j.cnki.1000-2707.2015.07.026

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