李云鸿,杜书敏,段宗刚,林慕之,周海燕,王艺明,刘兴德
LI Yunhong,DU Shumin,DUAN Zonggang,LIN Muzhi,ZHOU Haiyan,WANG Yiming,LIU Xingde

• 1:贵州医科大学附属医院
• 2:贵州中医药大学

摘要(Abstract)：

目的:分析非ST段抬高型急性冠脉综合征患者(NSTE-ACS)行经皮冠状动脉介入(PCI)术后再发不良心血管事件的相关影响因素。方法:根据患者PCI术后2年内是否再发心血管不良事件分为病例组(67例)和对照组(120例),比较两组患者一般资料(年龄、吸烟史、糖尿病史、高血压合并糖尿病史等)、术前外周血生化指标、术前血压及心率、术中病变血管数及置入支架数、术后双联抗血小板治疗(DAPT)时间等相关资料,对有统计学意义的指标行多因素Logistic回归分析,探讨影响NSTE-ACS患者PCI术后再发心血管不良事件的危险因素。结果:单因素分析显示,两组患者的年龄、吸烟史、糖尿病病史、高血压合并糖尿病史、肌钙蛋白T(c Tn T)、B型钠尿肽(BNP)、病变血管数、术后DAPT时间比较,差异有统计学意义(P <0. 05);多因素分析显示,影响患者预后的独立危险因素有高血压合并糖尿病史、BNP水平及术后DAPT时间<1年。结论:NSTE-ACS患者PCI术后2年内再发不良心血管事件与自身相关疾病史、发病时心肌缺血受损程度及抗血小板治疗有密切关联。
Objective: To analyze the recurrence-related factors of adverse cardiovascular events in patients with non-ST-segment elevation acute coronary syndrome( NSTE-ACS) undergoing percutaneous coronary intervention( PCI). Methods: According to whether patients had recurrence of cardiovascular adverse events within 2 years after PCI,patients with NSTE-ACS were divided into case group( 67 cases) and control group( 120 cases). The general data including age,smoking history,diabetes history,hypertension combined with diabetes were collected. The preoperative peripheral blood biochemical indicators,preoperative blood pressure and heart rate,intraoperative diseased blood vessels,stents and postoperative double antiplatelet therapy( DAPT) time were compared. The significantly different factors between two groups were further analyzed using multivariate logistic regression. Results: Between case and control groups,univariate analysis showed that there were significant differences in age,smoking history,diabetes history,hypertension and diabetes history,troponin T( cTnT),B-type natriuretic peptide( BNP),number of diseased blood vessels,DAPT time after operation( P < 0. 05). Multivariate analysis revealed that the independent risk factors affecting the prognosis of patients were history of hypertension with diabetes,BNP level,and postoperative DAPT time less than 1 year. Conclusion: The recurrence of adverse cardiovascular events within 2 years after PCI in patients with NSTE-ACS is closely related to patients' disease history,the degree of myocardial ischemic damage at the time of onset and antiplatelet therapy.

关键词(KeyWords)： 心血管疾病;心血管感染;血压;心率;危险因素;非ST段抬高型急性冠脉综合征;经皮冠状动脉
cardiovascular diseases;cardiovascular infections;blood pressure;heart rate;risk factors;non-ST-segment elevation acute coronary syndrome(NSTE-ACS);percutaneous coronary intervention(PCI)

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(31760294)

作者(Author): 李云鸿,杜书敏,段宗刚,林慕之,周海燕,王艺明,刘兴德
LI Yunhong,DU Shumin,DUAN Zonggang,LIN Muzhi,ZHOU Haiyan,WANG Yiming,LIU Xingde

DOI: 10.19367/j.cnki.2096-8388.2020.05.013

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