老年急性缺血性脑卒中并发卒中相关性肺炎的危险因素分析Relevant Factors of Stroke-associated Pneumonia in Elderly Patients with Acute Ischemic Stroke
庄景义,韦薇,周莉莉,詹克栋
ZHUANG Jingyi,WEI Wei,ZHOU Lili,ZHAN Kedong
摘要(Abstract):
目的:分析老年急性缺血性脑卒中并发卒中相关性肺炎(SAP)的相关影响因素。方法:58例老年(≥65岁)急性缺血性脑卒中并发SAP患者作为观察组,同期60例急性缺血性脑卒中未发生SAP患者作为对照组,比较2组患者的人口学资料(年龄、性别、职业、居住地等)、病情相关资料[吸烟史、饮酒史、吞咽障碍、肢体偏瘫、美国国立卫生研究院卒中量表(NIHSS)评分、Glasgow昏迷评定量表(GCS)评分、合并房颤、合并冠心病、合并糖尿病等]及医疗措施(行机械通气、肠内营养时长),对有统计学意义的指标行多因素Logistic回归分析,分析影响老年急性缺血性脑卒中并发SAP的高危因素。结果:单因素分析结果显示,2组患者年龄、吸烟史、饮酒史、吞咽障碍、肢体偏瘫、NIHSS评分、GCS评分、合并房颤、合并冠心病、合并糖尿病、行机械通气、肠内营养时长比较,差异有统计学意义(P<0.05);多因素Logistic分析结果显示,年龄≥75岁、有吸烟史、NIHSS≥15分、有吞咽障碍、有肢体偏瘫、GCS评分≤11分、合并房颤、合并冠心病、行机械通气、肠内营养时长≥1周是老年急性缺血性脑卒中并发SAP的高危因素。结论:老年急性缺血性脑卒中并发SAP影响因素以自身病情为主,其次还受到医疗因素影响。
Objective: To analyze the related factors of stroke-associated pneumonia(SAP) in elderly patients with acute ischemic stroke(AIS). Methods: From March 2017 to March 2018, 58 elderly patients with AIS complicated with SAP were enrolled as the observation group, and 60 elderly patients(≥65)served as the control group. The demographic data, illness data and medical measure data of the two groups were compared and analyzed, and multivariate logistic analysis was used to determine the related risk factors, and to explore the measures to prevent SAP in elderly patients with AIS. Result: Univariate correlation analysis showed that the factors influencing SAP in elderly patients with AIS were age, smoking history, drinking history, dysphagia, limb hemiplegia, NIHSS scores, GCS scores, atrial fibrillation, coronary heart disease, diabetes mellitus, mechanical ventilation, duration of enteral nutrition(P<0.05). Multivariate Logistic analysis showed that age(≥75 years old), smoking history, NIHSS(≥15), dysphagia, limb hemiplegia, GCS scores(≤11), atrial fibrillation, coronary heart disease, mechanical ventilation, enteral nutrition duration(≥1 week) were the high risk factors for SAP of elderly patients with AIS.Conclusion: The physical condition of elderly patients with AIS is generally poor. The main factors affecting SAP are the patients' own condition, and medical factors as well. The comprehensive situation of the patients should be comprehensively assessed, the advantages and disadvantages of the physical condition should be weighed. The medical measures should be carefully formulated to reduce the incidence of AIS and SAP.
关键词(KeyWords):
脑卒中,急性,缺血性;老年人;肺炎,卒中相关性;高危因素
stroke,acute,ischemic;elderly people;pneumonia,stroke-associated;high-risk factors
基金项目(Foundation): 国家自然科学基金项目(81860248)
作者(Author):
庄景义,韦薇,周莉莉,詹克栋
ZHUANG Jingyi,WEI Wei,ZHOU Lili,ZHAN Kedong
DOI: 10.19367/j.cnki.1000-2707.2019.11.019
参考文献(References):
- [1] CHEN L F,CHANG C Y,HSU L C,et al.Bacterial pneumonia following acute ischemic stroke[J].J Chin Med Assoc,2013,76(2):78-82.
- [2] 孙海欣,王文志.我国脑卒中流行状况及其防控策略[J].中华神经科杂志,2017,50(12):881-884.
- [3] 张娜,刘红.脑卒中相关性肺炎护理风险评价指标体系的构建[J].中国感染控制杂志,2019,18(3):220-224.
- [4] OVBIAGELE B,HILLS N K,SAVER J L,et al.Frequency and deter minants of pneumonia and urinary tract infection during stroke hospitalization[J].J Stroke Cerebrovasc Dis,2016,15:209-213.
- [5] 卒中相关性肺炎诊治中国专家共识组.卒中相关性肺炎诊治中国专家共识[J].中华内科学杂志,2010,49:1079.
- [6] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666-682.
- [7] JAUCH E C,SAVER J L,ADAMS H I,et a1.Guidelines for the early management ofpatients with acute ischemic stroke:a guideline for healthcare professionals from the American Heart Association/ American Stroke Association[J].Stroke,2013,44(3):870-947.
- [8] RUSANEN H,SAARINEN J T,SILLANPAA N.The association of blood pressure and collateral circulation in hyperacute ischemic stroke pa6ents treated with intravenous thrombolysis[J].Cerebrovasc Dis,2015,39(2):130-137.
- [9] 邬静密,谢浩芬,杨剑宏,等.早期肠内营养联合补充性肠外营养在老年急性缺血性脑卒中机械取栓术患者中的应用[J].中华现代护理杂志,2018,24(18):2128-2131.
- [10]刘丽萍,李曼,刘婧伊,等.2018年中国卒中管理及研究进展[J].临床荟萃,2019,34(1):5-10.
- [11]TZIOMALOS K,NTAIOS G,MIYAKIS S,et al.Prophylactic antibiotic treatment in severe acute ischemic stroke:the Antimicrobial chemop Rrophylaxis for Ischemic STrokE In MaceDonIa-Thrace Study (ARISTEIDIS) [J].Intern Emerg Med,2016,11(7):953-958.
- [12]DENNIS M,CASO V,KAPPELLE L J,et al.European stroke organisation(ESO) guidelines for prophylaxis for venous thromboembolism in immobile patients with acute ischaemic stroke[J].Eur Stroke J,2016,1(1):6-19.
- [13]YUAN M Z.LI F,TIAN X,et al .Risk factors for lung infection in stroke patients:ameta-analysis of observational studies[J].Expert Rev Antinfect Ther,2015,13(10):1289-1298.
- [14]SELLARS C,BOWIE L,BAGG J,et al.Risk factors for chest infection in acute stroke:a prospective cohort study[J].Stroke,2007,38(8):2284-2291.
- [15]KOENNECKE H C,BELZ W,BERFELDE D,et al.Factors influencing in hospital mortality and morbidity in-patients treated on a stroke unit [J].Neurology,2011,11(10):965-972.
- [16]潘希丁,周俊山.卒中相关性肺炎诊疗进展[J].医学综述,2018,24(3):538-542.
- [17]FUENTES B,NTAIOS G,PUTAALA J,et al .European stroke organisation (ESO) guidelines on glycaemia management in acute stroke[J].Eur Stroke J,2018,3(1):5-21.
- [18]JI R,LI G,ZHANG R,et al.Higher risk of deep vein thrombosis after hemorrhagic stroke than after acute ischemic stroke[J].J Vasc Nurs,2019,37(1):18-27.
- [19]MEINEL TR,KAESMACHER J,MORDASINI P,et al.Outcome,efficacy and safety of endovascular thrombectomy in ischaemic stroke according to time to reperfusion:data from a multicentre registry[J].Ther Adv Neurol Disord,2019,27(12):1756286419835708.
- [20]朱美红,时美芳,万里红,等.吞咽-摄食管理预防脑卒中吞咽障碍患者相关性肺炎的研究[J].中华护理杂志,2016,51(3):294-298.
- [21]BRAY B D,SMITH C J,CLOUD G C,et al.The association between delays in screening for and as8essing dysphagia after acute stmke,and the risk of stroke-associated pneumonia[J].J Neuml Neumsurg Psychiatry,2017,88(1):25-30.
- [22]SMITH C J,KISHORE A K,VAIL A,et al.Diagnosis of stroke-associated pneumonia:recommendations from the pneumonia in stroke consensu8 group[J].Stroke,2015,46(8):2335-2340.
- [23]HIEBER M,BARDUTZKY J.Immediate reversal of dabigatran by idarucizumab prior to laboratory and imaging results in acute stroke[J].Front Neurol,2019,15(10):230.
- [24]WANG C,DENG L,QIU S,et al.Serum albumin is negatively associated with hemorrhagic transformation in acute ischemicstroke patients[J].Cerebrovasc Dis,2019,47(1-2):88-94.
- [25]STABILE E,SCALISE M,FRANZESE M,et al.Role of carotid artery stenting in stroke prevention[J].G Ital Cardiol,2019,20(3):28-34.
- [26]DOROBISZ K,DOROBISZ T,JANCZAK D,et al.The evaluation of the sense of hearing in patients with carotid artery stenosis within the extracranial segments[J].Acta Neurol Belg,2018,119(3):385-392.
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