氟达拉滨联合表柔比星治疗复发难治性非霍奇金淋巴瘤60例
赖金火,王少元,林小燕,林碧娟
摘要(Abstract):
目的:探讨氟达拉滨联合表柔比星治疗复发难治性非霍奇金淋巴瘤的疗效。方法:60例复发难治性非霍奇金淋巴瘤患者随机分2组,实验组30例行氟达拉滨联合表柔比星治疗,对照组30例行氟达拉滨治疗;随访1~3年,对比治疗后第1和第4疗程的疗效和不良反应发生率,并统计第1、2及3年无病生存率。结果:两组内相比,治疗第4疗程后患者总有效率均优于治疗第1疗程后(P<0.05);两组间相比,治疗第4疗程后实验组患者总有效率,各项不良反应发生率,无病生存率均优于对照组(P<0.05)。结论:氟达拉滨联合表柔比星治疗复发难治性非霍奇金淋巴瘤,可以显著提高患者疗效,延长患者的生存期,提高患者的生命质量。
关键词(KeyWords):
氟达拉滨;表柔比星;淋巴瘤,非霍奇金;抗肿瘤联合化疗方案
基金项目(Foundation):
作者(Author):
赖金火,王少元,林小燕,林碧娟
DOI: 10.19367/j.cnki.1000-2707.2011.05.024
参考文献(References):
- [1]刘鹏飞,刘贤明,张会来,等.氟达拉滨联合表柔比星治疗复发难治性惰性非霍奇金淋巴瘤[J].中国肿瘤临床,2010(22):1313-1316.
- [2]Mannina D,Luminari S,Dondi A,et al.Long term out-come of patients with localized aggressive non-Hodgkinlymphoma treated with PROMECE-CYTABOM plus in-volved-field radiation therapy:a study by the Gruppo Ital-iano Studio Linfomi[J].Leuk-Lymphoma,2010(3):422-429.
- [3]Vallabhajosyula S,Baijal G,Vadhiraja BM,et al.Non-Hodgkin's lymphoma:is India ready to incorporate recentadvances in day to day practice[J].J Cancer Res Ther,2010(1):36-40.
- [4]Galetta F,Franzoni F,Cervetti G,et al.In vitro and in vi-vo study on the antioxidant activity of dexrazoxane[J].Bi-omed-Pharmacother,2010(4):259-263.
- [5]Laatiri MA,Elloumi M,Ali ZB,et al.Experience tunisi-enne dans la prise en charge des lymphomes agressifs de l'adulte:a propos de 337 patients[J].Bull Cancer,2010(4):409-416.
- [6]Sieniawski M,Bhartia S,Wilkinson J,et al.Incidence andoutcome of patients with diffuse large B cell lymphomawith marrow involvement and preliminary experience of anadult acute lymphoblastic leukemia protocol(NEALL VI)in cyclophosphamide,doxorubicin,vincristine,and pred-nisolone-rituximab refractory patients[J].Leuk Lympho-ma,2009(10):1726-1730.
- [7]Fridrik MA,Hausmaninger H,Lang A,Drach J,et al.Dose-dense therapy improves survival in aggressive non-Hodgkin's lymphoma[J].Ann Hematol,2010(3):273-282.
- [8]Ma X,Guo Y,Pang Z,et al.A randomized phase II studyof CEOP with or without semustine as induction chemo-therapy in patients with stage IE/IIE extranodal NK/T-celllymphoma,nasal type in the upper aerodigestive tract[J].Radiother Oncol,2009(3):492-497.
- [9]王华庆,邱立华,钱正子,等.氟达拉滨联合吡柔比星治疗复发难治性惰性非霍奇金淋巴瘤[J].白血病.淋巴瘤,2009(10):609-611,615.
- [10]徐晓红,杨磊,魏全芝,等.GDP方案治疗复发或难治性非霍奇金淋巴瘤的临床分析[J].实用临床医药杂志,2010(17):49-50.
- [11]Aviles A,Nambo MJ,Cleto S,et al.Rituximab and dose-dense chemotherapy in primary testicular lymphoma[J].Clin Lymphoma Myeloma,2009(5):386-389.
文章评论(Comment):
|
||||||||||||||||||
|