贵州医科大学学报

2015, v.40;No.176(05) 517-519+523

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肝细胞抗原在Barrett食管、反流性食管炎和食管腺癌中的表达和意义
Expression of Hepatocyte Antigen in Barrett Esophageal,Reflux Esophagitis and Esophageal Adenocarcinoma and Its Clinical Significance

许红;张永宏;
XU Hong;ZHANG Yonghong;Department of Gastroenterology,Guiyang Medical College;

摘要(Abstract):

目的:观察肝细胞抗原(Hep)在Barrett食管(BE)、反流性食管炎和食管腺癌中的表达,探讨其临床意义。方法:采用免疫组化En Vision法,检测Hep在正常食管黏膜组织(10例)、反流性食管炎(12例)、BE(28例)、食管腺癌(5例)中的表达,同时观察Hep在轻度、中度、重度肠化生型BE中的阳性率。结果:Hep在正常食管黏膜组织中的阳性率为20.0%,在反流性食管炎中的阳性率为16.7%,在Barrett食管中的阳性率为39.2%,其中轻、中、重度肠化Barrett食管Hep阳性率分别为25%,60%,100%,伴有异型增生Barrett食管3例为阴性表达,在食管腺癌中阳性率为60%。结论:随着Barrett食管肠化生程度的加重,Hep阳性表达率增高,Hep有望成为BE上皮化生的生物学标志物。
Objective: To study expression of hepatocyte antigen in Barrett esophageal,reflux esophagitis and esophageal adenocarcinoma and its clinical significance. Methods: The study consisted of10 cases of healthy volunteers,12 cases of reflux esophagitis,28 cases of Barrett's esophagus and 5 cases of esophageal adenocarcinoma. The esophageal mucosa among all enrolled cases were examined by immunohistochemical En Vision technique to detect the expression of hepatocyte antigen. Meanwhile,the positive rate of hepatocyte antigen in the Barrett esophagus with mild,moderate,severe intestinalmetaplasia-type were detected respectively. Results: The positive rate of hepatocyte antigen in healthy volunteers,reflux esophagitis and Barrett esophageal was 20%,16. 7%,39. 2%,respectively. Among the Barrett esophagus cases,the positive rate of hepatocyte antigen was 25% in 16 cases of mild intestinal metaplasia,60% in 5 cases of moderate intestinal metaplasia,100% in 4 cases of severe intestinal metaplasia and negative expression in 3 cases of dysplasia,respectively. The positive rate was60% in 5 cases of esophageal adenocarcinoma. Conclusions: With aggravation of intestinal metaplasia,the positive rate of hepatocyte antigen increases. Therefore,hepatocyte antigen may be expected to be a biological mark of the BE intestinal metaplasia and helpful for clinical diagnosis,treatment and prognosis of BE.

关键词(KeyWords): Barrett食管;肠化生;反流性食管炎;食管;腺癌;肝细胞抗原
Barrett esophagus;intestinal metaplasia;reflux esophagiti;esophagus;adenocarcinoma;hepatocyte antigen

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作者(Author): 许红;张永宏;
XU Hong;ZHANG Yonghong;Department of Gastroenterology,Guiyang Medical College;

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DOI: 10.19367/j.cnki.1000-2707.2015.05.025

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