任蕾,何俐
REN Lei,HE Li

• 1:湖北省十堰市人民医院口腔科

摘要(Abstract)：

目的:分析2型糖尿病伴牙周炎患者牙周治疗干预对糖脂质代谢及炎症因子的影响。方法:2型糖尿病伴牙周炎患者42例为研究对象,检测牙周治疗前后空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)等糖脂质代谢指标,同时检测肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、C-反应蛋白(CRP)、脂联素(APN)、瘦素(LEP)等血清炎症因子水平,并分析炎症因子间的相关性。结果:2型糖尿病伴牙周炎患者治疗后,FPG、Hb A1c及TG显著降低,与治疗前比较差异有统计学意义(P<0.001);TNF-α、IL-6、CRP及LEP显著降低,与治疗前比较差异有统计学意义(P<0.001);APN明显升高,与治疗前比较差异有统计学意义(t=4.245,P<0.001);血清APN与LEP及TNF-α水平呈现显著负相关(P<0.05)。结论:控制牙周炎可改善2型糖尿病伴牙周炎患者的糖脂质代谢紊乱。
Objective: To investigate the clinical effect of periodontitis treatment on glucose and lipid metabolism and inflammatory factors in periodontitis patients with Type 2 diabetes. Method: A total of42 patients of type 2 diabetes with periodontitis were analyzed. Glucose and lipid metabolism index levels such as FPG,Hb A1 c,TG,HDL-C and LDL-C were tested before and after periodontitis treatment.Meanwhile,serum inflammatory factors such as TNF-α,IL-6,CRP,APN and LEP were also tested.The correlation analysis of serum inflammatory factors was performed. Results: After treatment,patients got lower levels of FPG,Hb A1 cand TG when compared with those before treatment,differences were statistical significant( P < 0. 001); Meanwhile,TNF-α,IL-6,CRP and LEP were obviously lower than those before treatment,differences were statistical significant( P < 0. 001); Level of APN were higher than before treatment,the difference was statistically significant( t = 4. 245,P < 0. 001). The level of serum APN had significant negative correlation with TNF-α and LEP( P < 0. 05). Conclusion:Periodontitis treatment can improve metabolic disorders in patients with type 2 diabetes.

关键词(KeyWords)： 糖尿病,非胰岛素依赖型;牙周炎;代谢;炎症;肿瘤坏死因子;C反应蛋白质;瘦素
diabetes mellitus,non-insulin-dependent;periodontitis;metabolism;inflammation;tumer necrosts factor;C reactive protein;leptin

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 任蕾,何俐
REN Lei,HE Li

DOI: 10.19367/j.cnki.1000-2707.2015.08.031

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