杨媛;陈琛;冉利梅;杨星;闫雪秋;刘帝;
YANG Yuan;CHEN Chen;RAN Limei;YANG Xing;YAN Xueqiu;LIU Di;College of Public Health, Guizhou Medical University;Medical Examination Center,the Affiliated Hospital of Guizhou Medical University;College of Medicine and Health Management, Guizhou Medical University;

• 1:贵州医科大学公共卫生学院
• 2:贵州医科大学
• 3:贵州医科大学附院健康管理中心
• 4:贵州医科大学医药卫生管理学院

摘要(Abstract)：

目的:探讨围绝经期女性脑血管功能积分值与体质量指数(BMI)和血压水平的关系。方法:920例无卒中史的围绝经期女性,采用脑血管功能仪检测脑血管血流动力学指标、计算获取脑血管功能积分值,分为正常组(≥75分)和异常组(<75分),根据患者的BMI经患者分为体质量正常组、超重组和肥胖组,根据患者的血压水平将患者分为血压正常组、高血压1～3级(1、2、3级)组;比较异常脑血管功能积分值在不同年龄段的分布情况,分析围绝经期女性的BMI、血压水平与脑血管功能积分值的关系。结果:920名围绝经期女性中,脑血管功能积分值异常率为13.3%(122/920),且随年龄段的升高而升高,差异有统计学意义(χ■=23.283,P<0.01);体重正常组、超重组和肥胖组被检者的脑血管功能积分值异常率分别为8.8%、16.8%、38.5%,组间差异均具有统计学意义(P<0.01);血压正常组、一级高血压组、二级高血压组、三级高血压组被检者的脑血管功能积分值异常率分别为8.1%、48.1%、83.3%及100%,组间差异均有统计学意义(P<0.01)。结论:绝经期女性脑血管功能积分值与BMI和血压水平密切相关。
Objective: To investigate the association of brain vascular function scores with body mass index(BMI) and blood pressure levels of perimenopausal women. Methods: A total of 920 perimenopausal women without stroke history were enrolled. The cerebral vascular hemodynamics was detected by cerebrovascular function meter and the scores of cerebrovascular function were calculated to divide the enrollers into normal group(≥75 points) and abnormal group(<75). According to BMI, the enrollers were divided into the normal BMI group, overweight group and obese group. Based on blood pressure(BP) level, the enrollers were classified into the normal BP group and the high BP level 1 to 3(levels 1, 2, and 3). Abnormal cerebrovascular function scores was compared in different age groups. Moreover, the association between BMI and blood pressure level with cerebrovascular function scores was analyzed. Results: The abnormal rate of cerebrovascular function score was 13.3%(122/920), and it increased with age(χ²_(trend)=23.283, P<0.01). The abnormal rates of cerebrovascular function scores were 8.8%, 16.8% and 38.5% in the normal weight, overweight and obesity groups, respectively(P<0.01). Moreover, the abnormal rates of cerebrovascular function scores were 8.1%, 48.1%, 83.3% and 100% in the normal group, the first-grade hypertension group, the second-grade hypertension group, and the third-grade hypertension group(P<0.01). Conclusion: The scores of cerebrovascular function in perimenopausal women are closely related to BMI and blood pressure levels.

关键词(KeyWords)： 围绝经期;卒中;血流动力学;脑血管功能;危险因素;因素分析
perimenopause;stroke;hemodynamics;cerebrovascular function;risk factor;factor analysis

Abstract:

Keywords:

基金项目(Foundation): 中国健康促进基金会(zhjkglqct2018-88-01)

作者(Authors): 杨媛;陈琛;冉利梅;杨星;闫雪秋;刘帝;
YANG Yuan;CHEN Chen;RAN Limei;YANG Xing;YAN Xueqiu;LIU Di;College of Public Health, Guizhou Medical University;Medical Examination Center,the Affiliated Hospital of Guizhou Medical University;College of Medicine and Health Management, Guizhou Medical University;

DOI: 10.19367/j.cnki.1000-2707.2019.10.015

参考文献(References)：

• [1] 郭吉平,黄久仪,管阳太,等.脑血流动力学改变与脑卒中发病关系的列研究[J].中华预防医学杂志,2013,47(4):323-327.
• [2] 钟宇,李兰,刘婷婷,等.社区脑卒中高危个体筛查与干预管理模式探讨[J].重庆医学,2012,9(41):2903-2904.
• [3] 杨尚■.上海市杨浦区社区妇女围绝经期综合症的影响因素[D].苏州:苏州大学,2015.
• [4] 赵静,舒颖.北京市某社区脑卒中高危人群超重、肥胖现况调查[J].中华全科医学,2012,10(7):1115-11116;1125.
• [5] 王艳,黄久仪,曹奕丰,等.上海市奉贤社区脑卒中危险因素队列研究基线调查和随访分析[J].中华流行病学杂志,2007,28(12):1171-1174.
• [6] 杨媛,冉利梅,杨星,等.439例40～60岁围绝经期女性脑血管功能测评及影响因素分析[J].中华健康管理学杂志,2017,11(5):421-426.
• [7] 管向红,王冬梅,申素芳,等.声辐射力脉冲成像技术在评估颈部血管斑块中的应用价值[J].中国医疗设备,2014,29(11):160-162.
• [8] 中国肥胖问题工作组数据汇总分析协作组.我国成人体重指数和腰围对相关疾病危险因素异常的预测价值:适宜体重指数和腰围切点的研究[J].中华流行病学杂志,2002,23(1):5-10.
• [9] 《中国高血压基层管理指南》修订委员会.中国高血压基层管理指南(2014年修订版)[J].中华高血压杂志,2015,23(1):24-43.
• [10]ZHANG C,XIE S,LI S,et al.Flow patterns and wall shear stress distribution in human internal carotid arteries:the geometric effect on the risk for stenosis[J].J Biomech,2012,45(1):83-89.
• [11]王桂清,沈凤英,王艳,等.脑出血和脑梗死患者血液动力学检测比较[J].中华国际医学杂志,2001,(6):509-511.
• [12]张芬,余金明,胡大一,等.不同肥胖指标与脑卒中发生关系[J].中国公共卫生,2013,29(1):125-126.
• [13]KURTH T,GAZIANO J M,BERGER K,et al.Body mass index and the risk of stroke in men[J].Arch Intern Med,2002,162(22):2557-2562.
• [14]LISAK M,DEMARIN V,TRKANJEC Z,et al.Hypertriglyceridemia as a possible independent risk factor for stroke[J].Acta ClinCroat,2013,52(4):458-463.
• [15]MONTAGUE C T,PRINS J B,SANDERS L,et al.Depot-related gene expression in human subcutaneous and omentaladipocytes[J].Diabetes,1998,47(9):1384-1391.
• [16]邓少婷,张保红,胡冰,等.围绝经期妇女心血管疾病危险因素评估与管理[J].吉林医学,2013,34(9):1621-1622.
• [17]SNIGDER MB,VAN D R,VISSER M,et al.What aspects of body fat are particularly hazardous and how do we measure them[J].Int J Epidemiol,2006,35(1):83-92.
• [18]姚月娴,林金秀.腹型肥胖与脑卒中的关系[J].世界临床药物,2010,31(9):572-576.
• [19]闫丽,曹烨,汪秋实,等.高血压患者脑卒中发病影响因素Cox回归分析[J].中国公共卫生,2016,(6):748-752.
• [20]SARWAR N,GAO P,et al.Diabetes mellitus,fasting blood glucose concentration,and risk of vascular disease:a collaborative meta-analysis of 102 prospective studies[J].Lancet,2010,375(9733):2215-2222.
• [21]GLASSER S P,JUDD S,BASILE J,et al..Prehypertension,racial prevalence and its association with risk factors:Analysis of the REasons for Geographic And Racial Differences in Stroke ( REGARDS) study[J].Am J Hypertens,2011,24(2):194-199.
• [22]庞慧,付强,黄宜杰等,高血压患者十年脑卒中风险概率分析[J].中华脑血管病杂志,2012,6(5):261-265.
• [23]李喜梅,王瑜,叶燕珍,等.脑血管功能检测在早期筛查脑血管疾病中的应用价值[J].中国医疗设备,2015,30(9):40-43.

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